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Anticancer activity of a thymidine quinoxaline conjugate is modulated by cytosolic thymidine pathways

BACKGROUND: High levels of thymidine kinase 1 (TK1) and thymidine phosphorylase (TYMP) are key molecular targets by thymidine therapeutics in cancer treatment. The dual roles of TYMP as a tumor growth factor and a key activation enzyme of anticancer metabolites resulted in a mixed outcome in cancer...

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Detalles Bibliográficos
Autores principales:	Wei, Qiong, Liu, Haijuan, Zhou, Honghao, Zhang, Dejun, Zhang, Zhiwei, Zhou, Qibing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374574/ https://www.ncbi.nlm.nih.gov/pubmed/25881156 http://dx.doi.org/10.1186/s12885-015-1149-5

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