Effects of Resistance versus Endurance Training on Plasma Lipocalin-2 in Young Men

PURPOSE: Lipocalin-2 (Lcn2) has been recognized as an adipocyte-derived acute phase protein that is positively correlated with obesity, insulin resistance, type 2 diabetes, and cardiovascular disease. The effects of resistance and endurance training (RT vs. ET) on plasma lipocalin-2 are still unclear. Therefore, the purpose of this study was to examine the effects of RT vs. ET on plasma lipocalin-2 in young men. METHODS: Twenty nine healthy and sedentary young men (age, 21-29 years) participated in this study. The subjects were randomly assigned to RT group (n=9), ET group (n=10) or control group (n=10). The experimental groups performed either RT or ET, 3 days a week for 8 weeks. The endurance training program included continuous running at an intensity corresponding to 65–80% of maximal heart rate, while resistance training consisted of 2-4 sets of circuit weight training for 8 stations and at an intensity corresponding to 65-80% of 1-RM in each station. RESULTS: No significant changes in the body mass, BMI, body fat percentage and WHR were found after the RT and ET. The results showed that Lcn2 decreased after RT and ET compared with the control group (P<0.05). High sensitivity C-reactive protein (hs-CRP) and insulin resistance determined by HOMA-IR, did not change in the RT and ET compared with the control group. CONCLUSION: Lcn2 decreases after 8 weeks RT and ET, but this improvement was not accompanied by decreased hs-CRP and insulin resistance in healthy and sedentary young men.