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Effect of Pregabalin in Preventing Secondary Damage in Traumatic Brain Injury: An Experimental Study

BACKGROUND: In this study we aimed to explore the effects of pregabalin on a traumatic brain injury model in rats. MATERIAL/METHODS: This study included 40 adult male Sprague-Dawley rats randomized into 4 groups, each of which contained equal numbers of animals. The control group had no head trauma...

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Autores principales: Calikoglu, Cagatay, Aytekin, Hikmet, Akgül, Osman, Akgül, Mehmet Hüseyin, Gezen, Ahmet Ferruh, Akyuz, Feyzullah, Cakir, Murteza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374647/
https://www.ncbi.nlm.nih.gov/pubmed/25785578
http://dx.doi.org/10.12659/MSM.893887
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author Calikoglu, Cagatay
Aytekin, Hikmet
Akgül, Osman
Akgül, Mehmet Hüseyin
Gezen, Ahmet Ferruh
Akyuz, Feyzullah
Cakir, Murteza
author_facet Calikoglu, Cagatay
Aytekin, Hikmet
Akgül, Osman
Akgül, Mehmet Hüseyin
Gezen, Ahmet Ferruh
Akyuz, Feyzullah
Cakir, Murteza
author_sort Calikoglu, Cagatay
collection PubMed
description BACKGROUND: In this study we aimed to explore the effects of pregabalin on a traumatic brain injury model in rats. MATERIAL/METHODS: This study included 40 adult male Sprague-Dawley rats randomized into 4 groups, each of which contained equal numbers of animals. The control group had no head trauma and thus was not treated. The trauma group had head trauma but was not treated. The pregabalin group had no head trauma but was treated by pregabalin. The trauma + pregabalin group had head trauma treated with pregabalin. The biopsy samples taken from the study animals were histopathologically examined for the presence of edema, inflammation, and neuronal damage. RESULTS: All animals in the trauma group had edema, inflammation, and neuronal damage. Four subjects in the control group, 6 in the pregabalin group, and 4 in the trauma + pregabalin group had edema; inflammation was present in 1 subject in the control group, 3 subjects in the pregabalin group, and 3 subjects in the trauma + pregabalin group; neuronal damage existed in 1 subject in the control group, 1 subject in the pregabalin group, and 6 subjects in the trauma + pregabalin group. The trauma group had significantly higher edema and neuronal damage scores than the other groups. Similarly, inflammation was significantly more prevalent in the trauma group than the control and trauma + pregabalin groups. CONCLUSIONS: The results of the present study indicated anti-edema, anti-inflammatory, and neuroprotective effects of pregabalin in an experimental head trauma model in rats. Pregabalin may thus be beneficial in humans with acute TBI by relieving concomitant edema and inflammation.
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spelling pubmed-43746472015-04-01 Effect of Pregabalin in Preventing Secondary Damage in Traumatic Brain Injury: An Experimental Study Calikoglu, Cagatay Aytekin, Hikmet Akgül, Osman Akgül, Mehmet Hüseyin Gezen, Ahmet Ferruh Akyuz, Feyzullah Cakir, Murteza Med Sci Monit Animal Study BACKGROUND: In this study we aimed to explore the effects of pregabalin on a traumatic brain injury model in rats. MATERIAL/METHODS: This study included 40 adult male Sprague-Dawley rats randomized into 4 groups, each of which contained equal numbers of animals. The control group had no head trauma and thus was not treated. The trauma group had head trauma but was not treated. The pregabalin group had no head trauma but was treated by pregabalin. The trauma + pregabalin group had head trauma treated with pregabalin. The biopsy samples taken from the study animals were histopathologically examined for the presence of edema, inflammation, and neuronal damage. RESULTS: All animals in the trauma group had edema, inflammation, and neuronal damage. Four subjects in the control group, 6 in the pregabalin group, and 4 in the trauma + pregabalin group had edema; inflammation was present in 1 subject in the control group, 3 subjects in the pregabalin group, and 3 subjects in the trauma + pregabalin group; neuronal damage existed in 1 subject in the control group, 1 subject in the pregabalin group, and 6 subjects in the trauma + pregabalin group. The trauma group had significantly higher edema and neuronal damage scores than the other groups. Similarly, inflammation was significantly more prevalent in the trauma group than the control and trauma + pregabalin groups. CONCLUSIONS: The results of the present study indicated anti-edema, anti-inflammatory, and neuroprotective effects of pregabalin in an experimental head trauma model in rats. Pregabalin may thus be beneficial in humans with acute TBI by relieving concomitant edema and inflammation. International Scientific Literature, Inc. 2015-03-18 /pmc/articles/PMC4374647/ /pubmed/25785578 http://dx.doi.org/10.12659/MSM.893887 Text en © Med Sci Monit, 2015 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License
spellingShingle Animal Study
Calikoglu, Cagatay
Aytekin, Hikmet
Akgül, Osman
Akgül, Mehmet Hüseyin
Gezen, Ahmet Ferruh
Akyuz, Feyzullah
Cakir, Murteza
Effect of Pregabalin in Preventing Secondary Damage in Traumatic Brain Injury: An Experimental Study
title Effect of Pregabalin in Preventing Secondary Damage in Traumatic Brain Injury: An Experimental Study
title_full Effect of Pregabalin in Preventing Secondary Damage in Traumatic Brain Injury: An Experimental Study
title_fullStr Effect of Pregabalin in Preventing Secondary Damage in Traumatic Brain Injury: An Experimental Study
title_full_unstemmed Effect of Pregabalin in Preventing Secondary Damage in Traumatic Brain Injury: An Experimental Study
title_short Effect of Pregabalin in Preventing Secondary Damage in Traumatic Brain Injury: An Experimental Study
title_sort effect of pregabalin in preventing secondary damage in traumatic brain injury: an experimental study
topic Animal Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374647/
https://www.ncbi.nlm.nih.gov/pubmed/25785578
http://dx.doi.org/10.12659/MSM.893887
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