Fluorogenic Probe for the Human Ether-a-Go-Go-Related Gene Potassium Channel Imaging

[Image: see text] The first small-molecule fluorogenic probe A1 for imaging the human Ether-a-go-go-Related Gene (hERG) potassium channel based on the photoinduced electron transfer (PET) off–on mechanism was described herein. After careful biological evaluation, this probe had the potential of dete...

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Autores principales: Liu, Zhenzhen, Wang, Beilei, Ma, Zhao, Zhou, Yubin, Du, Lupei, Li, Minyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374661/
https://www.ncbi.nlm.nih.gov/pubmed/25665091
http://dx.doi.org/10.1021/ac504763b
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author Liu, Zhenzhen
Wang, Beilei
Ma, Zhao
Zhou, Yubin
Du, Lupei
Li, Minyong
author_facet Liu, Zhenzhen
Wang, Beilei
Ma, Zhao
Zhou, Yubin
Du, Lupei
Li, Minyong
author_sort Liu, Zhenzhen
collection PubMed
description [Image: see text] The first small-molecule fluorogenic probe A1 for imaging the human Ether-a-go-go-Related Gene (hERG) potassium channel based on the photoinduced electron transfer (PET) off–on mechanism was described herein. After careful biological evaluation, this probe had the potential of detecting and imaging the hERG channel at the molecular and cellular level. Moreover, the competitive binding mechanism of this probe would presumably minimize the effects on the electrophysiological properties of the hERG channel. Therefore, this probe may serve as a powerful toolkit to the hERG-associated study.
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spelling pubmed-43746612016-02-09 Fluorogenic Probe for the Human Ether-a-Go-Go-Related Gene Potassium Channel Imaging Liu, Zhenzhen Wang, Beilei Ma, Zhao Zhou, Yubin Du, Lupei Li, Minyong Anal Chem [Image: see text] The first small-molecule fluorogenic probe A1 for imaging the human Ether-a-go-go-Related Gene (hERG) potassium channel based on the photoinduced electron transfer (PET) off–on mechanism was described herein. After careful biological evaluation, this probe had the potential of detecting and imaging the hERG channel at the molecular and cellular level. Moreover, the competitive binding mechanism of this probe would presumably minimize the effects on the electrophysiological properties of the hERG channel. Therefore, this probe may serve as a powerful toolkit to the hERG-associated study. American Chemical Society 2015-02-09 2015-03-03 /pmc/articles/PMC4374661/ /pubmed/25665091 http://dx.doi.org/10.1021/ac504763b Text en Copyright © 2015 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Liu, Zhenzhen
Wang, Beilei
Ma, Zhao
Zhou, Yubin
Du, Lupei
Li, Minyong
Fluorogenic Probe for the Human Ether-a-Go-Go-Related Gene Potassium Channel Imaging
title Fluorogenic Probe for the Human Ether-a-Go-Go-Related Gene Potassium Channel Imaging
title_full Fluorogenic Probe for the Human Ether-a-Go-Go-Related Gene Potassium Channel Imaging
title_fullStr Fluorogenic Probe for the Human Ether-a-Go-Go-Related Gene Potassium Channel Imaging
title_full_unstemmed Fluorogenic Probe for the Human Ether-a-Go-Go-Related Gene Potassium Channel Imaging
title_short Fluorogenic Probe for the Human Ether-a-Go-Go-Related Gene Potassium Channel Imaging
title_sort fluorogenic probe for the human ether-a-go-go-related gene potassium channel imaging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374661/
https://www.ncbi.nlm.nih.gov/pubmed/25665091
http://dx.doi.org/10.1021/ac504763b
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