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Removal of Endotoxins from Bacteriophage Preparations by Extraction with Organic Solvents
Lipopolysaccharide (LPS, endotoxin, pyrogen) constitutes a very troubling contaminant of crude phage lysates produced in Gram-negative bacteria. Toxicity of LPS depends on the strong innate immunity response including the cytokines. Therefore, its removal is important for bacteriophage applications....
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374689/ https://www.ncbi.nlm.nih.gov/pubmed/25811193 http://dx.doi.org/10.1371/journal.pone.0122672 |