Bladder Cancer Screening in Aluminum Smelter Workers

OBJECTIVE: To present results of a bladder cancer screening program conducted in 18 aluminum smelters in the United States from January 2000 to December 2010. METHODS: Data were collected on a cohort of workers with a history of working in coal tar pitch volatile exposed areas including urine analys...

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Detalles Bibliográficos
Autores principales: Taiwo, Oyebode A., Slade, Martin D., Cantley, Linda F., Tessier-Sherman, Baylah, Galusha, Deron, Kirsche, Sharon R., Donoghue, A. Michael, Cullen, Mark R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American College of Occupational and Environmental Medicine 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374722/
https://www.ncbi.nlm.nih.gov/pubmed/25525927
http://dx.doi.org/10.1097/JOM.0000000000000377
Descripción
Sumario:OBJECTIVE: To present results of a bladder cancer screening program conducted in 18 aluminum smelters in the United States from January 2000 to December 2010. METHODS: Data were collected on a cohort of workers with a history of working in coal tar pitch volatile exposed areas including urine analysis for conventional cytology and ImmunoCyt/uCyt+ assay. RESULTS: ImmunoCyt/uCyt+ and cytology in combination showed a sensitivity of 62.30%, a specificity of 92.60%, a negative predictive value of 99.90%, and a positive predictive value of 2.96%. Fourteen cases of bladder cancer were detected, and the standardized incidence ratio of bladder cancer was 1.18 (95% confidence interval, 0.65 to 1.99). Individuals who tested positive on either test who were later determined to be cancer free had undergone expensive and invasive tests. CONCLUSIONS: Evidence to support continued surveillance of this cohort has not been demonstrated.

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