Hepatocyte- Specific Deletion of ARNT (Aryl Hydrocarbon Receptor Nuclear Translocator) Results in Altered Fibrotic Gene Expression in the Thioacetamide Model of Liver Injury

BACKGROUND & AIMS: Recent studies have shown that increased expression of liver hypoxia inducible factor 2-α (HIF-2α) leads to liver inflammation and a pro-fibrotic gene expression signature. Aryl hydrocarbon Receptor Nuclear Translocator (ARNT) is required for HIF-2α transcriptional activity an...

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Detalles Bibliográficos
Autores principales: Scott, Christopher, Cha, Kuan, Rao, Renuka, Liddle, Christopher, George, Jacob, Gunton, Jenny E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374875/
https://www.ncbi.nlm.nih.gov/pubmed/25812120
http://dx.doi.org/10.1371/journal.pone.0121650

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374875/
https://www.ncbi.nlm.nih.gov/pubmed/25812120
http://dx.doi.org/10.1371/journal.pone.0121650

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