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Serotonin and Noradrenaline Reuptake Inhibitors Improve Micturition Control in Mice
Poor micturition control may cause profound distress, because proper voiding is mandatory for an active social life. Micturition results from the subtle interplay of central and peripheral components. It involves the coordination of autonomic and neuromuscular activity at the brainstem level, under...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374881/ https://www.ncbi.nlm.nih.gov/pubmed/25812116 http://dx.doi.org/10.1371/journal.pone.0121883 |
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author | Redaelli, Marco Ricatti, María Jimena Simonetto, Marialaura Claus, Mirko Ballabio, Maurizio Caretta, Antonio Mucignat-Caretta, Carla |
author_facet | Redaelli, Marco Ricatti, María Jimena Simonetto, Marialaura Claus, Mirko Ballabio, Maurizio Caretta, Antonio Mucignat-Caretta, Carla |
author_sort | Redaelli, Marco |
collection | PubMed |
description | Poor micturition control may cause profound distress, because proper voiding is mandatory for an active social life. Micturition results from the subtle interplay of central and peripheral components. It involves the coordination of autonomic and neuromuscular activity at the brainstem level, under the executive control of the prefrontal cortex. We tested the hypothesis that administration of molecules acting as reuptake inhibitors of serotonin, noradrenaline or both may exert a strong effect on the control of urine release, in a mouse model of overactive bladder. Mice were injected with cyclophosphamide (40 mg/kg), to increase micturition acts. Mice were then given one of four molecules: the serotonin reuptake inhibitor imipramine, its metabolite desipramine that acts on noradrenaline reuptake, the serotonin and noradrenaline reuptake inhibitor duloxetine or its active metabolite 4-hydroxy-duloxetine. Cyclophosphamide increased urine release without inducing overt toxicity or inflammation, except for increase in urothelium thickness. All the antidepressants were able to decrease the cyclophosphamide effects, as apparent from longer latency to the first micturition act, decreased number of urine spots and volume of released urine. These results suggest that serotonin and noradrenaline reuptake inhibitors exert a strong and effective modulatory effect on the control of urine release and prompt to additional studies on their central effects on brain areas involved in the social and behavioral control of micturition. |
format | Online Article Text |
id | pubmed-4374881 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-43748812015-04-04 Serotonin and Noradrenaline Reuptake Inhibitors Improve Micturition Control in Mice Redaelli, Marco Ricatti, María Jimena Simonetto, Marialaura Claus, Mirko Ballabio, Maurizio Caretta, Antonio Mucignat-Caretta, Carla PLoS One Research Article Poor micturition control may cause profound distress, because proper voiding is mandatory for an active social life. Micturition results from the subtle interplay of central and peripheral components. It involves the coordination of autonomic and neuromuscular activity at the brainstem level, under the executive control of the prefrontal cortex. We tested the hypothesis that administration of molecules acting as reuptake inhibitors of serotonin, noradrenaline or both may exert a strong effect on the control of urine release, in a mouse model of overactive bladder. Mice were injected with cyclophosphamide (40 mg/kg), to increase micturition acts. Mice were then given one of four molecules: the serotonin reuptake inhibitor imipramine, its metabolite desipramine that acts on noradrenaline reuptake, the serotonin and noradrenaline reuptake inhibitor duloxetine or its active metabolite 4-hydroxy-duloxetine. Cyclophosphamide increased urine release without inducing overt toxicity or inflammation, except for increase in urothelium thickness. All the antidepressants were able to decrease the cyclophosphamide effects, as apparent from longer latency to the first micturition act, decreased number of urine spots and volume of released urine. These results suggest that serotonin and noradrenaline reuptake inhibitors exert a strong and effective modulatory effect on the control of urine release and prompt to additional studies on their central effects on brain areas involved in the social and behavioral control of micturition. Public Library of Science 2015-03-26 /pmc/articles/PMC4374881/ /pubmed/25812116 http://dx.doi.org/10.1371/journal.pone.0121883 Text en © 2015 Redaelli et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Redaelli, Marco Ricatti, María Jimena Simonetto, Marialaura Claus, Mirko Ballabio, Maurizio Caretta, Antonio Mucignat-Caretta, Carla Serotonin and Noradrenaline Reuptake Inhibitors Improve Micturition Control in Mice |
title | Serotonin and Noradrenaline Reuptake Inhibitors Improve Micturition Control in Mice |
title_full | Serotonin and Noradrenaline Reuptake Inhibitors Improve Micturition Control in Mice |
title_fullStr | Serotonin and Noradrenaline Reuptake Inhibitors Improve Micturition Control in Mice |
title_full_unstemmed | Serotonin and Noradrenaline Reuptake Inhibitors Improve Micturition Control in Mice |
title_short | Serotonin and Noradrenaline Reuptake Inhibitors Improve Micturition Control in Mice |
title_sort | serotonin and noradrenaline reuptake inhibitors improve micturition control in mice |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374881/ https://www.ncbi.nlm.nih.gov/pubmed/25812116 http://dx.doi.org/10.1371/journal.pone.0121883 |
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