Targeted Deletion of the Murine Lgr4 Gene Decreases Lens Epithelial Cell Resistance to Oxidative Stress and Induces Age-Related Cataract Formation

Oxidative stress contributes to the formation of cataracts. The leucine rich repeat containing G protein-coupled receptor 4 (LGR4, also known as GPR48), is important in many developmental processes. Since deletion of Lgr4 has previously been shown to lead to cataract formation in mice, we sought to...

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Detalles Bibliográficos
Autores principales: Zhu, Jun, Hou, Qiang, Dong, Xiang Da, Wang, Zhenlian, Chen, Xiaoyan, Zheng, Dandan, Zhou, Linglin, He, Chao, Liu, Mingyao, Tu, LiLi, Qu, Jia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374889/
https://www.ncbi.nlm.nih.gov/pubmed/25811370
http://dx.doi.org/10.1371/journal.pone.0119599

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