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Lipoprotein Lipase SNPs rs13702 and rs301 Correlate with Clinical Outcome in Chronic Lymphocytic Leukemia Patients

Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world and is characterized by a heterogeneous clinical course. This variability in clinical course has spiked the search for prognostic markers able to predict patient evolution at the moment of diagnosis. Markers demonstr...

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Autores principales: Rombout, Ans, Stamatopoulos, Basile, Lagneaux, Laurence, Lust, Sofie, Offner, Fritz, Naessens, Evelien, Vanderstraeten, Hanne, Verhasselt, Bruno, Philippé, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374908/
https://www.ncbi.nlm.nih.gov/pubmed/25811490
http://dx.doi.org/10.1371/journal.pone.0121526
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author Rombout, Ans
Stamatopoulos, Basile
Lagneaux, Laurence
Lust, Sofie
Offner, Fritz
Naessens, Evelien
Vanderstraeten, Hanne
Verhasselt, Bruno
Philippé, Jan
author_facet Rombout, Ans
Stamatopoulos, Basile
Lagneaux, Laurence
Lust, Sofie
Offner, Fritz
Naessens, Evelien
Vanderstraeten, Hanne
Verhasselt, Bruno
Philippé, Jan
author_sort Rombout, Ans
collection PubMed
description Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world and is characterized by a heterogeneous clinical course. This variability in clinical course has spiked the search for prognostic markers able to predict patient evolution at the moment of diagnosis. Markers demonstrated to be of value are the mutation status of the immunoglobulin heavy chain variable region genes (IGHV) and lipoprotein lipase (LPL) expression. High LPL mRNA expression has been associated with short treatment free (TFS) and decreased overall survival (OS) in CLL. The LPL SNPs rs301 (T<C), rs328 (C<G) and rs13702 (T<C) have been associated with various metabolic disorders, but the association with CLL evolution is unknown. Here, in a cohort of 248 patients, we show that patients with the LPL SNP rs13702 wild-type T/T genotype had significantly shorter OS than patients with C/C and T/C genotypes (median time until CLL related death: 90 and 156 months respectively, p=0.008). The same was observed for LPL SNP rs301 (median time until CLL related death T/T: 102 and C/C, T/C: 144 months, p=0.03). Both SNPs rs301 and rs13702 were significantly associated with each other and notably, no association was found between IGHV status and presence of the SNP genotypes, indicating that these LPL SNPs are reliable prognostic markers that could add extra prognostic and predictive information to classical markers and help to improve the management of CLL.
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spelling pubmed-43749082015-04-04 Lipoprotein Lipase SNPs rs13702 and rs301 Correlate with Clinical Outcome in Chronic Lymphocytic Leukemia Patients Rombout, Ans Stamatopoulos, Basile Lagneaux, Laurence Lust, Sofie Offner, Fritz Naessens, Evelien Vanderstraeten, Hanne Verhasselt, Bruno Philippé, Jan PLoS One Research Article Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world and is characterized by a heterogeneous clinical course. This variability in clinical course has spiked the search for prognostic markers able to predict patient evolution at the moment of diagnosis. Markers demonstrated to be of value are the mutation status of the immunoglobulin heavy chain variable region genes (IGHV) and lipoprotein lipase (LPL) expression. High LPL mRNA expression has been associated with short treatment free (TFS) and decreased overall survival (OS) in CLL. The LPL SNPs rs301 (T<C), rs328 (C<G) and rs13702 (T<C) have been associated with various metabolic disorders, but the association with CLL evolution is unknown. Here, in a cohort of 248 patients, we show that patients with the LPL SNP rs13702 wild-type T/T genotype had significantly shorter OS than patients with C/C and T/C genotypes (median time until CLL related death: 90 and 156 months respectively, p=0.008). The same was observed for LPL SNP rs301 (median time until CLL related death T/T: 102 and C/C, T/C: 144 months, p=0.03). Both SNPs rs301 and rs13702 were significantly associated with each other and notably, no association was found between IGHV status and presence of the SNP genotypes, indicating that these LPL SNPs are reliable prognostic markers that could add extra prognostic and predictive information to classical markers and help to improve the management of CLL. Public Library of Science 2015-03-26 /pmc/articles/PMC4374908/ /pubmed/25811490 http://dx.doi.org/10.1371/journal.pone.0121526 Text en © 2015 Rombout et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Rombout, Ans
Stamatopoulos, Basile
Lagneaux, Laurence
Lust, Sofie
Offner, Fritz
Naessens, Evelien
Vanderstraeten, Hanne
Verhasselt, Bruno
Philippé, Jan
Lipoprotein Lipase SNPs rs13702 and rs301 Correlate with Clinical Outcome in Chronic Lymphocytic Leukemia Patients
title Lipoprotein Lipase SNPs rs13702 and rs301 Correlate with Clinical Outcome in Chronic Lymphocytic Leukemia Patients
title_full Lipoprotein Lipase SNPs rs13702 and rs301 Correlate with Clinical Outcome in Chronic Lymphocytic Leukemia Patients
title_fullStr Lipoprotein Lipase SNPs rs13702 and rs301 Correlate with Clinical Outcome in Chronic Lymphocytic Leukemia Patients
title_full_unstemmed Lipoprotein Lipase SNPs rs13702 and rs301 Correlate with Clinical Outcome in Chronic Lymphocytic Leukemia Patients
title_short Lipoprotein Lipase SNPs rs13702 and rs301 Correlate with Clinical Outcome in Chronic Lymphocytic Leukemia Patients
title_sort lipoprotein lipase snps rs13702 and rs301 correlate with clinical outcome in chronic lymphocytic leukemia patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374908/
https://www.ncbi.nlm.nih.gov/pubmed/25811490
http://dx.doi.org/10.1371/journal.pone.0121526
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