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Identification of Small Molecules that Disrupt Signaling between ABL and Its Positive Regulator RIN1
Constitutively active BCR-ABL kinase fusions are causative mutations in the pathogenesis of hematopoietic neoplasias including chronic myelogenous leukemia (CML). Although these fusions have been successfully targeted with kinase inhibitors, drug-resistance and relapse continue to limit long-term su...
Autores principales: | Ting, Pamela Y., Damoiseaux, Robert, Titz, Björn, Bradley, Kenneth A., Graeber, Thomas G., Fernández-Vega, Virneliz, Bannister, Thomas D., Chase, Peter, Nair, Reji, Scampavia, Louis, Hodder, Peter, Spicer, Timothy P., Colicelli, John |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374917/ https://www.ncbi.nlm.nih.gov/pubmed/25811598 http://dx.doi.org/10.1371/journal.pone.0121833 |
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