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Epidemiology of Chronic Kidney Disease, With Special Emphasis on Chronic Kidney Disease of Uncertain Etiology, in the North Central Region of Sri Lanka
BACKGROUND: The aim of the study was to identify the epidemiology of chronic kidney disease of uncertain etiology in Sri Lanka. METHODS: A cross-sectional study was carried out by analyzing health statistics, and three cohort studies were conducted (n = 15 630, 3996, and 2809) to analyze the demogra...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Japan Epidemiological Association
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375281/ https://www.ncbi.nlm.nih.gov/pubmed/25787679 http://dx.doi.org/10.2188/jea.JE20140074 |
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author | Jayasekara, Kithsiri Bandara Dissanayake, Dhammika Menike Sivakanesan, Ramiah Ranasinghe, Asanga Karunarathna, Ranawaka Hewage Priyantha Kumara, Gardiye Waligamage Gamini |
author_facet | Jayasekara, Kithsiri Bandara Dissanayake, Dhammika Menike Sivakanesan, Ramiah Ranasinghe, Asanga Karunarathna, Ranawaka Hewage Priyantha Kumara, Gardiye Waligamage Gamini |
author_sort | Jayasekara, Kithsiri Bandara |
collection | PubMed |
description | BACKGROUND: The aim of the study was to identify the epidemiology of chronic kidney disease of uncertain etiology in Sri Lanka. METHODS: A cross-sectional study was carried out by analyzing health statistics, and three cohort studies were conducted (n = 15 630, 3996, and 2809) to analyze the demographic information, age-specific prevalence, etiology, and stage of presentation. We screened 7604 individuals for chronic kidney disease of uncertain etiology. RESULTS: The results showed that the male:female ratio was 2.4:1, the mean age of patients was 54.7 ± 8 years, 92% of the patients were farmers, and 93% consumed water from shallow dug wells. Familial occurrence was common (36%). The prevalence of chronic kidney disease in different age groups was 3% in those aged 30–40 years; 7% in those aged 41–50 years, 20% in those aged 51–60 years, and 29% in those older than 60 years. Chronic kidney disease of uncertain etiology was diagnosed in 70.2% of patients, while 15.7% and 9.6% were due to hypertension and diabetic mellitus, respectively. The majority of patients were stage 4 (40%) at first presentation, while 31.8% were stage 3 and 24.5% were stage 5. Stage 1 and 2 presentation accounted for only 3.4%. CONCLUSIONS: Low prevalence of CKDU was noticed (1.5%) among those who consumed water from natural springs. Prevalence was highest among males, rice farming communities, and those presenting at later disease stages. |
format | Online Article Text |
id | pubmed-4375281 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Japan Epidemiological Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-43752812015-04-05 Epidemiology of Chronic Kidney Disease, With Special Emphasis on Chronic Kidney Disease of Uncertain Etiology, in the North Central Region of Sri Lanka Jayasekara, Kithsiri Bandara Dissanayake, Dhammika Menike Sivakanesan, Ramiah Ranasinghe, Asanga Karunarathna, Ranawaka Hewage Priyantha Kumara, Gardiye Waligamage Gamini J Epidemiol Original Article BACKGROUND: The aim of the study was to identify the epidemiology of chronic kidney disease of uncertain etiology in Sri Lanka. METHODS: A cross-sectional study was carried out by analyzing health statistics, and three cohort studies were conducted (n = 15 630, 3996, and 2809) to analyze the demographic information, age-specific prevalence, etiology, and stage of presentation. We screened 7604 individuals for chronic kidney disease of uncertain etiology. RESULTS: The results showed that the male:female ratio was 2.4:1, the mean age of patients was 54.7 ± 8 years, 92% of the patients were farmers, and 93% consumed water from shallow dug wells. Familial occurrence was common (36%). The prevalence of chronic kidney disease in different age groups was 3% in those aged 30–40 years; 7% in those aged 41–50 years, 20% in those aged 51–60 years, and 29% in those older than 60 years. Chronic kidney disease of uncertain etiology was diagnosed in 70.2% of patients, while 15.7% and 9.6% were due to hypertension and diabetic mellitus, respectively. The majority of patients were stage 4 (40%) at first presentation, while 31.8% were stage 3 and 24.5% were stage 5. Stage 1 and 2 presentation accounted for only 3.4%. CONCLUSIONS: Low prevalence of CKDU was noticed (1.5%) among those who consumed water from natural springs. Prevalence was highest among males, rice farming communities, and those presenting at later disease stages. Japan Epidemiological Association 2015-04-05 /pmc/articles/PMC4375281/ /pubmed/25787679 http://dx.doi.org/10.2188/jea.JE20140074 Text en © 2015 Kithsiri Bandara Jayasekara et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Original Article Jayasekara, Kithsiri Bandara Dissanayake, Dhammika Menike Sivakanesan, Ramiah Ranasinghe, Asanga Karunarathna, Ranawaka Hewage Priyantha Kumara, Gardiye Waligamage Gamini Epidemiology of Chronic Kidney Disease, With Special Emphasis on Chronic Kidney Disease of Uncertain Etiology, in the North Central Region of Sri Lanka |
title | Epidemiology of Chronic Kidney Disease, With Special Emphasis on Chronic Kidney Disease of Uncertain Etiology, in the North Central Region of Sri Lanka |
title_full | Epidemiology of Chronic Kidney Disease, With Special Emphasis on Chronic Kidney Disease of Uncertain Etiology, in the North Central Region of Sri Lanka |
title_fullStr | Epidemiology of Chronic Kidney Disease, With Special Emphasis on Chronic Kidney Disease of Uncertain Etiology, in the North Central Region of Sri Lanka |
title_full_unstemmed | Epidemiology of Chronic Kidney Disease, With Special Emphasis on Chronic Kidney Disease of Uncertain Etiology, in the North Central Region of Sri Lanka |
title_short | Epidemiology of Chronic Kidney Disease, With Special Emphasis on Chronic Kidney Disease of Uncertain Etiology, in the North Central Region of Sri Lanka |
title_sort | epidemiology of chronic kidney disease, with special emphasis on chronic kidney disease of uncertain etiology, in the north central region of sri lanka |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375281/ https://www.ncbi.nlm.nih.gov/pubmed/25787679 http://dx.doi.org/10.2188/jea.JE20140074 |
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