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Trends in Thermostability Provide Information on the Nature of Substrate, Inhibitor, and Lipid Interactions with Mitochondrial Carriers

Mitochondrial carriers, including uncoupling proteins, are unstable in detergents, which hampers structural and mechanistic studies. To investigate carrier stability, we have purified ligand-free carriers and assessed their stability with a fluorescence-based thermostability assay that monitors prot...

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Detalles Bibliográficos
Autores principales:	Crichton, Paul G., Lee, Yang, Ruprecht, Jonathan J., Cerson, Elizabeth, Thangaratnarajah, Chancievan, King, Martin S., Kunji, Edmund R. S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2015
Materias:	Bioenergetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375477/ https://www.ncbi.nlm.nih.gov/pubmed/25653283 http://dx.doi.org/10.1074/jbc.M114.616607

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