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Return of pandemic H1N1 influenza virus
BACKGROUND: Influenza pandemics are usually caused by the re-assortment of several influenza viruses, results in the emergence of new influenza virus strains that can infect the entire population. These pandemic strains, as well as seasonal influenza viruses, are subjected to extensive antigenic cha...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375933/ https://www.ncbi.nlm.nih.gov/pubmed/25551676 http://dx.doi.org/10.1186/s12879-014-0710-1 |
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author | Sherbany, Hilda McCauley, John Meningher, Tal Hindiyeh, Musa Dichtiar, Rita Markovich, Michal Perry Mendelson, Ella Mandelboim, Michal |
author_facet | Sherbany, Hilda McCauley, John Meningher, Tal Hindiyeh, Musa Dichtiar, Rita Markovich, Michal Perry Mendelson, Ella Mandelboim, Michal |
author_sort | Sherbany, Hilda |
collection | PubMed |
description | BACKGROUND: Influenza pandemics are usually caused by the re-assortment of several influenza viruses, results in the emergence of new influenza virus strains that can infect the entire population. These pandemic strains, as well as seasonal influenza viruses, are subjected to extensive antigenic change that has, so far, prevented the generation of a universal vaccine. METHODS: Samples of patients hospitalized due to infection with the pandemic H1N1 influenza virus (A(H1N1)pdm09) from 2009, when the virus first appeared, until 2013 were analyzed. RESULTS: While many patients were hospitalized in 2009 due to infection with the pandemic H1N1 influenza virus, only small percentages of patients were hospitalized later in 2010–2012. Surprisingly, however in 2012–2013, we noticed that the percentages of patients hospitalized due to the pandemic H1N1 influenza infection increased significantly. Moreover, the ages of hospitalized patients differed throughout this entire period (2009–2013) and pregnant women were especially vulnerable to the infection. CONCLUSIONS: High percentages of patients (especially pregnant women) were hospitalized in 2013 due to the A(H1N1)pdm09 infection, which may have been enabled by an antigenic drift from those which circulated at the onset of the pandemic. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12879-014-0710-1) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4375933 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-43759332015-03-28 Return of pandemic H1N1 influenza virus Sherbany, Hilda McCauley, John Meningher, Tal Hindiyeh, Musa Dichtiar, Rita Markovich, Michal Perry Mendelson, Ella Mandelboim, Michal BMC Infect Dis Research Article BACKGROUND: Influenza pandemics are usually caused by the re-assortment of several influenza viruses, results in the emergence of new influenza virus strains that can infect the entire population. These pandemic strains, as well as seasonal influenza viruses, are subjected to extensive antigenic change that has, so far, prevented the generation of a universal vaccine. METHODS: Samples of patients hospitalized due to infection with the pandemic H1N1 influenza virus (A(H1N1)pdm09) from 2009, when the virus first appeared, until 2013 were analyzed. RESULTS: While many patients were hospitalized in 2009 due to infection with the pandemic H1N1 influenza virus, only small percentages of patients were hospitalized later in 2010–2012. Surprisingly, however in 2012–2013, we noticed that the percentages of patients hospitalized due to the pandemic H1N1 influenza infection increased significantly. Moreover, the ages of hospitalized patients differed throughout this entire period (2009–2013) and pregnant women were especially vulnerable to the infection. CONCLUSIONS: High percentages of patients (especially pregnant women) were hospitalized in 2013 due to the A(H1N1)pdm09 infection, which may have been enabled by an antigenic drift from those which circulated at the onset of the pandemic. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12879-014-0710-1) contains supplementary material, which is available to authorized users. BioMed Central 2014-12-31 /pmc/articles/PMC4375933/ /pubmed/25551676 http://dx.doi.org/10.1186/s12879-014-0710-1 Text en © Sherbany et al.; licensee BioMed Central. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Sherbany, Hilda McCauley, John Meningher, Tal Hindiyeh, Musa Dichtiar, Rita Markovich, Michal Perry Mendelson, Ella Mandelboim, Michal Return of pandemic H1N1 influenza virus |
title | Return of pandemic H1N1 influenza virus |
title_full | Return of pandemic H1N1 influenza virus |
title_fullStr | Return of pandemic H1N1 influenza virus |
title_full_unstemmed | Return of pandemic H1N1 influenza virus |
title_short | Return of pandemic H1N1 influenza virus |
title_sort | return of pandemic h1n1 influenza virus |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375933/ https://www.ncbi.nlm.nih.gov/pubmed/25551676 http://dx.doi.org/10.1186/s12879-014-0710-1 |
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