The association constant of 5′,8-cyclo-2′-deoxyguanosine with cytidine

The association of 5′,8-cyclo-2′-deoxyguanosine (cdG), a DNA tandem lesion, with its complementary base cytosine has been studied by voltammetry and NMR in chloroform, using properly silylated derivatives of the two nucleobases for increasing their solubilities. Both voltammetric data and NMR titrat...

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Detalles Bibliográficos
Autores principales: Capobianco, Amedeo, Caruso, Tonino, Fusco, Sandra, Terzidis, Michael A., Masi, Annalisa, Chatgilialoglu, Chryssostomos, Peluso, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376000/
https://www.ncbi.nlm.nih.gov/pubmed/25870853
http://dx.doi.org/10.3389/fchem.2015.00022
Descripción
Sumario:The association of 5′,8-cyclo-2′-deoxyguanosine (cdG), a DNA tandem lesion, with its complementary base cytosine has been studied by voltammetry and NMR in chloroform, using properly silylated derivatives of the two nucleobases for increasing their solubilities. Both voltammetric data and NMR titrations indicated that the Watson-Crick complex of cytidine with cdG is weaker than that with guanosine, the difference being approximately of one order of magnitude between the two association constants.

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