The association constant of 5′,8-cyclo-2′-deoxyguanosine with cytidine

The association of 5′,8-cyclo-2′-deoxyguanosine (cdG), a DNA tandem lesion, with its complementary base cytosine has been studied by voltammetry and NMR in chloroform, using properly silylated derivatives of the two nucleobases for increasing their solubilities. Both voltammetric data and NMR titrat...

Descripción completa

Detalles Bibliográficos
Autores principales: Capobianco, Amedeo, Caruso, Tonino, Fusco, Sandra, Terzidis, Michael A., Masi, Annalisa, Chatgilialoglu, Chryssostomos, Peluso, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376000/
https://www.ncbi.nlm.nih.gov/pubmed/25870853
http://dx.doi.org/10.3389/fchem.2015.00022
_version_ 1782363664410476544
author Capobianco, Amedeo
Caruso, Tonino
Fusco, Sandra
Terzidis, Michael A.
Masi, Annalisa
Chatgilialoglu, Chryssostomos
Peluso, Andrea
author_facet Capobianco, Amedeo
Caruso, Tonino
Fusco, Sandra
Terzidis, Michael A.
Masi, Annalisa
Chatgilialoglu, Chryssostomos
Peluso, Andrea
author_sort Capobianco, Amedeo
collection PubMed
description The association of 5′,8-cyclo-2′-deoxyguanosine (cdG), a DNA tandem lesion, with its complementary base cytosine has been studied by voltammetry and NMR in chloroform, using properly silylated derivatives of the two nucleobases for increasing their solubilities. Both voltammetric data and NMR titrations indicated that the Watson-Crick complex of cytidine with cdG is weaker than that with guanosine, the difference being approximately of one order of magnitude between the two association constants.
format Online
Article
Text
id pubmed-4376000
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-43760002015-04-13 The association constant of 5′,8-cyclo-2′-deoxyguanosine with cytidine Capobianco, Amedeo Caruso, Tonino Fusco, Sandra Terzidis, Michael A. Masi, Annalisa Chatgilialoglu, Chryssostomos Peluso, Andrea Front Chem Chemistry The association of 5′,8-cyclo-2′-deoxyguanosine (cdG), a DNA tandem lesion, with its complementary base cytosine has been studied by voltammetry and NMR in chloroform, using properly silylated derivatives of the two nucleobases for increasing their solubilities. Both voltammetric data and NMR titrations indicated that the Watson-Crick complex of cytidine with cdG is weaker than that with guanosine, the difference being approximately of one order of magnitude between the two association constants. Frontiers Media S.A. 2015-03-27 /pmc/articles/PMC4376000/ /pubmed/25870853 http://dx.doi.org/10.3389/fchem.2015.00022 Text en Copyright © 2015 Capobianco, Caruso, Fusco, Terzidis, Masi, Chatgilialoglu and Peluso. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Capobianco, Amedeo
Caruso, Tonino
Fusco, Sandra
Terzidis, Michael A.
Masi, Annalisa
Chatgilialoglu, Chryssostomos
Peluso, Andrea
The association constant of 5′,8-cyclo-2′-deoxyguanosine with cytidine
title The association constant of 5′,8-cyclo-2′-deoxyguanosine with cytidine
title_full The association constant of 5′,8-cyclo-2′-deoxyguanosine with cytidine
title_fullStr The association constant of 5′,8-cyclo-2′-deoxyguanosine with cytidine
title_full_unstemmed The association constant of 5′,8-cyclo-2′-deoxyguanosine with cytidine
title_short The association constant of 5′,8-cyclo-2′-deoxyguanosine with cytidine
title_sort association constant of 5′,8-cyclo-2′-deoxyguanosine with cytidine
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376000/
https://www.ncbi.nlm.nih.gov/pubmed/25870853
http://dx.doi.org/10.3389/fchem.2015.00022
work_keys_str_mv AT capobiancoamedeo theassociationconstantof58cyclo2deoxyguanosinewithcytidine
AT carusotonino theassociationconstantof58cyclo2deoxyguanosinewithcytidine
AT fuscosandra theassociationconstantof58cyclo2deoxyguanosinewithcytidine
AT terzidismichaela theassociationconstantof58cyclo2deoxyguanosinewithcytidine
AT masiannalisa theassociationconstantof58cyclo2deoxyguanosinewithcytidine
AT chatgilialogluchryssostomos theassociationconstantof58cyclo2deoxyguanosinewithcytidine
AT pelusoandrea theassociationconstantof58cyclo2deoxyguanosinewithcytidine
AT capobiancoamedeo associationconstantof58cyclo2deoxyguanosinewithcytidine
AT carusotonino associationconstantof58cyclo2deoxyguanosinewithcytidine
AT fuscosandra associationconstantof58cyclo2deoxyguanosinewithcytidine
AT terzidismichaela associationconstantof58cyclo2deoxyguanosinewithcytidine
AT masiannalisa associationconstantof58cyclo2deoxyguanosinewithcytidine
AT chatgilialogluchryssostomos associationconstantof58cyclo2deoxyguanosinewithcytidine
AT pelusoandrea associationconstantof58cyclo2deoxyguanosinewithcytidine

Ejemplares similares