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DNA damage in BALB/c mice infected with Lacazia loboi and its relation to nutritional status

BACKGROUND: Jorge Lobo’s disease, also known as lacaziosis, is a cutaneous-subcutaneous mycosis with chronic evolution. It is caused by the fungus Lacazia loboi. Herein we report a study that relates the genotoxicity caused by L. loboi in isogenic mice with nutritional status, through a normal or re...

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Detalles Bibliográficos
Autores principales: Barbosa, Adriana Sierra Assencio Almeida, de Oliveira, Larissa Ragozo Cardoso, Tavares, Francilene Capel, de Lima, Carlos Roberto Gonçalves, Diório, Suzana Madeira, Calvi, Sueli Aparecida, Vilani-Moreno, Fátima Regina, Pereira, Paulo Câmara Marques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376161/
https://www.ncbi.nlm.nih.gov/pubmed/25821459
http://dx.doi.org/10.1186/s40409-015-0006-y
Descripción
Sumario:BACKGROUND: Jorge Lobo’s disease, also known as lacaziosis, is a cutaneous-subcutaneous mycosis with chronic evolution. It is caused by the fungus Lacazia loboi. Herein we report a study that relates the genotoxicity caused by L. loboi in isogenic mice with nutritional status, through a normal or restricted diet. METHODS: DNA damage was assessed in the peripheral blood by the comet assay (tail intensity). RESULTS: The results for leukocytes showed increases in the mean tail intensity in mice under dietary restriction, in infected mice under dietary restriction and in infected mice ingesting a normal diet. CONCLUSION: These results indicate that dietary restriction and L. loboi infection may increase DNA damage levels in mice, as detected by the comet assay.