Cargando…

Single and multiple dose pharmacokinetics and tolerability of HX-1171, a novel antioxidant, in healthy volunteers

BACKGROUND: HX-1171 (1-O-hexyl-2,3,5-trimethylhydroquinone) is a promising antioxidant with therapeutic potential for hepatic fibrosis. The aim of this study was to investigate the tolerability and pharmacokinetics of HX-1171 in healthy volunteers. METHODS: A randomized, single-blind, placebo-contro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Yo Han, Choi, Hee Youn, Lee, Shi Hyang, Lim, Hyeong-Seok, Miki, Tokutaro, Kang, Jong-Koo, Han, Kyoung-Goo, Bae, Kyun-Seop
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2015
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376184/ https://www.ncbi.nlm.nih.gov/pubmed/25848210 http://dx.doi.org/10.2147/DDDT.S79724

Ejemplares similares

Pharmacokinetic interactions and tolerability of rosuvastatin and ezetimibe: an open-label, randomized, multiple-dose, crossover study in healthy male volunteers
por: Kim, Hyungsub, et al.
Publicado: (2018)

Evaluation of Pharmacokinetic Drug Interactions Between Gemigliptin (Dipeptidylpeptidase-4 Inhibitor) and Glimepiride (Sulfonylurea) in Healthy Volunteers
por: Choi, Hee Youn, et al.
Publicado: (2014)

Pharmacokinetic interaction between udenafil and dapoxetine: a randomized, open-labeled crossover study in healthy male volunteers
por: Kim, Yo Han, et al.
Publicado: (2015)

Single dose pharmacokinetics of the novel transdermal donepezil patch in healthy volunteers
por: Kim, Yo Han, et al.
Publicado: (2015)

First-in-Human Evaluation of the Safety, Tolerability, and Pharmacokinetics of a Neuroprotective Poly (ADP‐ribose) Polymerase‐1 Inhibitor, JPI-289, in Healthy Volunteers
por: Han, Sungpil, et al.
Publicado: (2020)

Pharmacokinetic comparison of sustained- and immediate-release formulations of cilostazol after multiple oral doses in fed healthy male Korean volunteers
por: Kim, Yo Han, et al.
Publicado: (2015)

HX-1171 attenuates pancreatic β-cell apoptosis and hyperglycemia-mediated oxidative stress via Nrf2 activation in streptozotocin-induced diabetic model
por: Kim, Jimin, et al.
Publicado: (2018)

Dose proportionality and pharmacokinetics of carvedilol sustained-release formulation: a single dose-ascending 10-sequence incomplete block study
por: Kim, Yo Han, et al.
Publicado: (2015)

Pharmacokinetic Interactions Between Bazedoxifene and Cholecalciferol: An Open-Label, Randomized, Crossover Study in Healthy Male Volunteers
por: Lee, Moon Hee, et al.
Publicado: (2023)

Pharmacokinetic Evaluation by Modeling and Simulation Analysis of a Donepezil Patch Formulation in Healthy Male Volunteers
por: Yoon, Seok Kyu, et al.
Publicado: (2020)

Pharmacokinetic Equivalence of the High Dose Strength Fixed-Dose Combination Tablet of Gemigliptin/Metformin Sustained Release (SR) and Individual Component Gemigliptin and Metformin XR Tablets in Healthy Subjects
por: Cho, Yong-Soon, et al.
Publicado: (2018)

Breaking the HxNy outbreak
por: Manikandan, Jayapal, et al.
Publicado: (2010)

Forensic science meets clinical pharmacology: pharmacokinetic model based estimation of alcohol concentration of a defendant as requested by a local prosecutor's office
por: Lim, Hyeong-Seok, et al.
Publicado: (2017)

Pharmacokinetic Drug Interaction Between Amlodipine and Tadalafil: An Open-Label, Randomized, Multiple-Dose Crossover Study in Healthy Male Volunteers
por: Kim, Hyungsub, et al.
Publicado: (2022)

Thermal Properties of Bayfol(®) HX200 Photopolymer
por: Blanche, Pierre-Alexandre, et al.
Publicado: (2020)

Pharmacokinetics and tolerability of artesunate and amodiaquine alone and in combination in healthy volunteers
por: Orrell, Catherine, et al.
Publicado: (2008)

Effect of Probenecid on Pharmacokinetics and Tolerability of Olmesartan in Healthy Chinese Volunteers()
por: Li, Kun-Yan, et al.
Publicado: (2014)

Safety, tolerability and pharmacokinetics of subcutaneous and intravenous anifrolumab in healthy volunteers
por: Tummala, Raj, et al.
Publicado: (2018)

Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Oral Venglustat in Healthy Volunteers
por: Peterschmitt, M. Judith, et al.
Publicado: (2020)

The Chemistry and Physics of Bayfol(®) HX Film Holographic Photopolymer
por: Bruder, Friedrich-Karl, et al.
Publicado: (2017)

Effects of dexamethasone coadministered with oseltamivir on the pharmacokinetics of oseltamivir in healthy volunteers
por: Jang, Kyungho, et al.
Publicado: (2017)

Specification for EEV CX 1171A thyratrons for application in the FAK system
Publicado: (1976)

Pharmacokinetics, safety and tolerability of human recombinant alkaline phosphatase in healthy volunteers
por: Peters, E, et al.
Publicado: (2015)

Safety, Tolerability and Pharmacokinetics of Single and Repeat Doses of Vixotrigine in Healthy Volunteers
por: Naik, Himanshu, et al.
Publicado: (2020)

Evaluation of the safety, tolerability, and pharmacokinetics of RO7049389 in healthy Chinese volunteers
por: Wu, Xiaojie, et al.
Publicado: (2021)

Tolerability and pharmacokinetic evaluation of inhaled dry powder hydroxychloroquine in healthy volunteers
por: de Reus, Y. A., et al.
Publicado: (2022)

Comparison of Pharmacodynamics between Tegoprazan and Dexlansoprazole Regarding Nocturnal Acid Breakthrough: A Randomized Crossover Study
por: Han, Sungpil, et al.
Publicado: (2023)

Efficacy and Safety of the Medium Cut-Off Elisio HX Dialyzer
por: Maduell, Francisco, et al.
Publicado: (2023)

Pharmacokinetic modeling of a novel hypoxia PET tracer [(18)F]HX4 in patients with non-small cell lung cancer
por: Verwer, E. E., et al.
Publicado: (2016)

Whole-genome sequencing of 1,171 elderly admixed individuals from Brazil
por: Naslavsky, Michel S., et al.
Publicado: (2022)

1171. Epidemiology of Old World Cutaneous Leishmaniasis among Members of the U.S. Military
por: Cebula, Brenan R, et al.
Publicado: (2022)

The Effect of Food and Formulation on the Pharmacokinetics, Safety, and Tolerability of GSK1322322 in Healthy Volunteers
por: Naderer, Odin, et al.
Publicado: (2015)

Pharmacokinetics, Pharmacodynamics, and Tolerability of Concomitant Administration of Verinurad and Febuxostat in Healthy Male Volunteers
por: Hall, Jesse, et al.
Publicado: (2018)

Comparable Pharmacokinetics, Safety, and Tolerability of Etrolizumab Administered by Prefilled Syringe or Autoinjector in a Randomized Trial in Healthy Volunteers
por: Zhang, Wenhui, et al.
Publicado: (2021)

1171. Measles and Rubella Seroprevalence among HIV-infected and uninfected Children and Adults in Zambia
por: Yang, Yangyupei, et al.
Publicado: (2021)

USL255 extended-release topiramate: Dose-proportional pharmacokinetics and tolerability in healthy volunteers
por: Clark, Annie M, et al.
Publicado: (2014)

Pharmacokinetics and Tolerability of Single and Multiple Intravenous Doses of Cefotetan Disodium in Healthy Chinese Volunteers
por: Liu, Jian, et al.
Publicado: (2020)

Phase 1 study to access safety, tolerability, pharmacokinetics, and pharmacodynamics of kynurenine in healthy volunteers
por: Al‐Karagholi, Mohammad Al‐Mahdi, et al.
Publicado: (2021)

Pharmacokinetics, Safety, and Tolerability of Single-Dose Orally Administered Venglustat in Healthy Chinese Volunteers
por: Li, Yingxin, et al.
Publicado: (2023)

Analysis of relative displacement between the HX wearable robotic exoskeleton and the user’s hand
por: Cempini, Marco, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_0rccuc25g7lhqk4o34e1tlju5p