Comparison of two self-assembled macromolecular prodrug micelles with different conjugate positions of SN38 for enhancing antitumor activity

7-Ethyl-10-hydroxycamptothecin (SN38), an active metabolite of irinotecan (CPT-11), is a remarkably potent antitumor agent. The clinical application of SN38 has been extremely restricted by its insolubility in water. In this study, we successfully synthesized two macromolecular prodrugs of SN38 with...

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Detalles Bibliográficos
Autores principales: Liu, Yi, Piao, Hongyu, Gao, Ying, Xu, Caihong, Tian, Ye, Wang, Lihong, Liu, Jinwen, Tang, Bo, Zou, Meijuan, Cheng, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376263/
https://www.ncbi.nlm.nih.gov/pubmed/25848251
http://dx.doi.org/10.2147/IJN.S77957

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376263/
https://www.ncbi.nlm.nih.gov/pubmed/25848251
http://dx.doi.org/10.2147/IJN.S77957

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