Cargando…

Comparison of two self-assembled macromolecular prodrug micelles with different conjugate positions of SN38 for enhancing antitumor activity

7-Ethyl-10-hydroxycamptothecin (SN38), an active metabolite of irinotecan (CPT-11), is a remarkably potent antitumor agent. The clinical application of SN38 has been extremely restricted by its insolubility in water. In this study, we successfully synthesized two macromolecular prodrugs of SN38 with...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Yi, Piao, Hongyu, Gao, Ying, Xu, Caihong, Tian, Ye, Wang, Lihong, Liu, Jinwen, Tang, Bo, Zou, Meijuan, Cheng, Gang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2015
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376263/ https://www.ncbi.nlm.nih.gov/pubmed/25848251 http://dx.doi.org/10.2147/IJN.S77957

Ejemplares similares

Synthesis and Antitumor Evaluation of Biotin-SN38-Valproic Acid Conjugates
por: Dai, Yi, et al.
Publicado: (2023)

One-step mechanochemical preparation and prominent antitumor activity of SN-38 self-micelle solid dispersion
por: Sun, Xuanrong, et al.
Publicado: (2019)

Investigation into the Efficacy of Val-SN-38, a Valine-Ester Prodrug of the Anti-Cancer Agent SN-38
por: Kwak, Eun-Young, et al.
Publicado: (2012)

Does sacituzumab-govitecan act as a conventional antibody drug conjugate (ADC), a prodrug of SN-38 or both?
por: Santi, Daniel V., et al.
Publicado: (2021)

Synthesis, characterization, and evaluation of mPEG–SN38 and mPEG–PLA–SN38 micelles for cancer therapy
por: Xie, Jing, et al.
Publicado: (2016)

Development of Self-Associating SN-38-Conjugated Poly(ethylene oxide)-Poly(ester) Micelles for Colorectal Cancer Therapy
por: Sadat, Sams M. A., et al.
Publicado: (2020)

β-Cyclodextrin-Based Inclusion Complexation Bridged Biodegradable Self-Assembly Macromolecular Micelle for the Delivery of Paclitaxel
por: Chen, Yanzuo, et al.
Publicado: (2016)

Liposomal codelivery of an SN38 prodrug and a survivin siRNA for tumor therapy
por: Bi, Ye, et al.
Publicado: (2018)

Novel SN38 derivative-based liposome as anticancer prodrug: an in vitro and in vivo study
por: Wu, Chan, et al.
Publicado: (2018)

Novel lipophilic SN38 prodrug forming stable liposomes for colorectal carcinoma therapy
por: Xing, Jing, et al.
Publicado: (2019)

Fabrication and characterization of a novel self-assembling micelle based on chitosan cross-linked pectin–doxorubicin conjugates macromolecular pro-drug for targeted cancer therapy
por: Li, Zhi-Ping, et al.
Publicado: (2018)

A Phase I/II Study for Dose-finding, and to Investigate the Safety, Pharmacokinetics and Preliminary Efficacy of NK012, an SN-38-Incorporating Macromolecular Polymeric Micelle, in Patients with Multiple Myeloma
por: Ri, Masaki, et al.
Publicado: (2017)

Synthesis and Biological Evaluation of Novel 10-Substituted-7-ethyl-10-hydroxycamptothecin (SN-38) Prodrugs
por: Zhou, Mo, et al.
Publicado: (2014)

Reduction of liver fibrosis by rationally designed macromolecular telmisartan prodrugs
por: Golder, Matthew R., et al.
Publicado: (2018)

Pharmacokinetics of a ternary conjugate based pH-responsive 10-HCPT prodrug nano-micelle delivery system
por: Liu, Yang, et al.
Publicado: (2017)

A Micelle Self-Assembled from Doxorubicin-Arabinoxylan Conjugates with pH-Cleavable Bond for Synergistic Antitumor Therapy
por: Wang, Jie, et al.
Publicado: (2017)

Enhancing the antitumor activity of tea polyphenols encapsulated in biodegradable nanogels by macromolecular self-assembly
por: Liu, Chen, et al.
Publicado: (2019)

Redox-Responsive Disulfide Bond-Bridged mPEG-PBLA Prodrug Micelles for Enhanced Paclitaxel Biosafety and Antitumor Efficacy
por: Chang, Sheng, et al.
Publicado: (2019)

Photo-responsive polymeric micelles and prodrugs: synthesis and characterization
por: Wang, Shiu-Wei, et al.
Publicado: (2018)

Fuel-driven macromolecular coacervation in complex coacervate core micelles
por: Lewis, Reece W., et al.
Publicado: (2022)

Characterization and Pharmacokinetic Study of Aprepitant Solid Dispersions with Soluplus(®)
por: Liu, Jinwen, et al.
Publicado: (2015)

Synthesis and evaluation of highly releasable and structurally stable antibody-SN-38-conjugates
por: Liu, Lianqi, et al.
Publicado: (2021)

Antitumor effect and metabonomics of niclosamide micelles
por: Hang, Jiarong, et al.
Publicado: (2022)

Heparin-Regulated Prodrug-Type Macromolecular Theranostic Systems for Cancer Therapy
por: Wang, Huiyuan, et al.
Publicado: (2017)

Carbon dots conjugated to SN38 for improved colorectal anticancer therapy
por: Mattinzoli, Deborah, et al.
Publicado: (2022)

PEGylation of lipophilic SN38 prodrug with DSPE-mPEG(2000) versus cremophor EL: comparative study for intravenous chemotherapy
por: Zeng, Jun, et al.
Publicado: (2019)

Curcumin-loaded redox response of self-assembled micelles for enhanced antitumor and anti-inflammation efficacy
por: Zhao, Shuang, et al.
Publicado: (2017)

IT-141, a Polymer Micelle Encapsulating SN-38, Induces Tumor Regression in Multiple Colorectal Cancer Models
por: Carie, Adam, et al.
Publicado: (2011)

Poly(Styrene-Co-Maleic Acid)-Conjugated 6-Aminofluorescein and Rhodamine Micelle as Macromolecular Fluorescent Probes for Micro-Tumors Detection and Imaging
por: Bharate, Gahininath Y., et al.
Publicado: (2022)

In Vitro and In Vivo Evaluation of Microparticulate Drug Delivery Systems Composed of Macromolecular Prodrugs
por: Onishi, Hiraku, et al.
Publicado: (2008)

Nucleic Acids as a Nature‐Inspired Scaffold for Macromolecular Prodrugs of Nucleoside Analogues
por: Krüger, Franziska, et al.
Publicado: (2019)

Macromolecular prodrugs of ribavirin: towards a treatment for co-infection with HIV and HCV
por: Smith, Anton A. A., et al.
Publicado: (2015)

Disulfide Bond-Based SN38 Prodrug Nanoassemblies with High Drug Loading and Reduction-Triggered Drug Release for Pancreatic Cancer Therapy
por: Zhong, Zhi-Xin, et al.
Publicado: (2023)

Probing the fluorination effect on the self-assembly characteristics, in vivo fate and antitumor efficacy of paclitaxel prodrug nanoassemblies
por: Wang, Xin, et al.
Publicado: (2021)

Tumor microenvironment-responsive micelles assembled from a prodrug of mitoxantrone and 1-methyl tryptophan for enhanced chemo-immunotherapy
por: Wang, Ru, et al.
Publicado: (2023)

Spatiotemporal Control of Doxorubicin Delivery from “Stealth-Like” Prodrug Micelles
por: Kong, Li, et al.
Publicado: (2017)

TPGS2000-DOX Prodrug Micelles for Improving Breast Cancer Therapy
por: Tang, Lan, et al.
Publicado: (2021)

Correction: Paclitaxel prodrug based mixed micelles for tumor-targeted chemotherapy
por: Tang, Dongyang, et al.
Publicado: (2020)

From prodrug to pro-prodrug: hypoxia-sensitive antibody–drug conjugates
por: Wang, Yanming, et al.
Publicado: (2022)

Enhanced antitumor effect of anti-tissue factor antibody-conjugated epirubicin-incorporating micelles in xenograft models
por: Yamamoto, Yoshiyuki, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_ul30623k8hg9heri2hcb9q0q7h