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Corneal Limbal Stem Cell Deficiency Associated with the Anticancer Drug S-1

PURPOSE: An oral antineoplastic drug, S-1, is known to be more effective with less toxicity and fewer gastrointestinal side effects than the conventional intravenous 5-fluorouracil. We report a case of limbal stem cell deficiency that occurred in a patient receiving chemotherapy using S-1 alone for...

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Autores principales: Kim, Kyeong Hwan, Kim, Wan Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376272/
https://www.ncbi.nlm.nih.gov/pubmed/25756340
http://dx.doi.org/10.1097/OPX.0000000000000543
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author Kim, Kyeong Hwan
Kim, Wan Soo
author_facet Kim, Kyeong Hwan
Kim, Wan Soo
author_sort Kim, Kyeong Hwan
collection PubMed
description PURPOSE: An oral antineoplastic drug, S-1, is known to be more effective with less toxicity and fewer gastrointestinal side effects than the conventional intravenous 5-fluorouracil. We report a case of limbal stem cell deficiency that occurred in a patient receiving chemotherapy using S-1 alone for gastric cancer. CASE REPORT: A 65-year-old woman with symptoms of grittiness and epiphora in both eyes for several months was referred to the ophthalmology clinic. She had been receiving S-1 orally after total gastrectomy for advanced gastric cancer. Slit lamp examination revealed an irregular hazy corneal epithelium in both eyes that extended to the center of the cornea overlying the pupil and showed late staining with fluorescein dye. Palisades of Vogt at the superior limbus were absent in both eyes. Best-corrected distance vision was 20/50 in both eyes with all other structures of the anterior and posterior segment unremarkable including a patent lacrimal drainage system. There was no change in the corneal lesions of either eye despite 3 months of topical therapy. The lesions did resolve in 4 months after discontinuation of S-1 therapy owing to acute renal failure. CONCLUSIONS: Early detection of this adverse reaction before significant visual loss through regular follow-up appears to be important in patients receiving S-1 therapy.
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spelling pubmed-43762722015-04-06 Corneal Limbal Stem Cell Deficiency Associated with the Anticancer Drug S-1 Kim, Kyeong Hwan Kim, Wan Soo Optom Vis Sci Clinical Cases PURPOSE: An oral antineoplastic drug, S-1, is known to be more effective with less toxicity and fewer gastrointestinal side effects than the conventional intravenous 5-fluorouracil. We report a case of limbal stem cell deficiency that occurred in a patient receiving chemotherapy using S-1 alone for gastric cancer. CASE REPORT: A 65-year-old woman with symptoms of grittiness and epiphora in both eyes for several months was referred to the ophthalmology clinic. She had been receiving S-1 orally after total gastrectomy for advanced gastric cancer. Slit lamp examination revealed an irregular hazy corneal epithelium in both eyes that extended to the center of the cornea overlying the pupil and showed late staining with fluorescein dye. Palisades of Vogt at the superior limbus were absent in both eyes. Best-corrected distance vision was 20/50 in both eyes with all other structures of the anterior and posterior segment unremarkable including a patent lacrimal drainage system. There was no change in the corneal lesions of either eye despite 3 months of topical therapy. The lesions did resolve in 4 months after discontinuation of S-1 therapy owing to acute renal failure. CONCLUSIONS: Early detection of this adverse reaction before significant visual loss through regular follow-up appears to be important in patients receiving S-1 therapy. Lippincott Williams & Wilkins 2015-04 2015-03-27 /pmc/articles/PMC4376272/ /pubmed/25756340 http://dx.doi.org/10.1097/OPX.0000000000000543 Text en Copyright © 2015 American Academy of Optometry This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.
spellingShingle Clinical Cases
Kim, Kyeong Hwan
Kim, Wan Soo
Corneal Limbal Stem Cell Deficiency Associated with the Anticancer Drug S-1
title Corneal Limbal Stem Cell Deficiency Associated with the Anticancer Drug S-1
title_full Corneal Limbal Stem Cell Deficiency Associated with the Anticancer Drug S-1
title_fullStr Corneal Limbal Stem Cell Deficiency Associated with the Anticancer Drug S-1
title_full_unstemmed Corneal Limbal Stem Cell Deficiency Associated with the Anticancer Drug S-1
title_short Corneal Limbal Stem Cell Deficiency Associated with the Anticancer Drug S-1
title_sort corneal limbal stem cell deficiency associated with the anticancer drug s-1
topic Clinical Cases
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376272/
https://www.ncbi.nlm.nih.gov/pubmed/25756340
http://dx.doi.org/10.1097/OPX.0000000000000543
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