A case of Hodgkin’s lymphoma with severely impaired liver function treated successfully with gemcitabine followed by ABVD

Hodgkin’s lymphoma (HL) originates from clonal B cells and is the most common malignancy in the second decade of life. Liver involvement is uncommon at presentation in patients with HL and there is a paucity of data for treatment of patients with severely impaired liver function. We present an unusu...

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Autores principales: Chakraborty, Rajshekhar, Mukkamalla, Shiva Kumar Reddy, Gutzmore, Garfield, Chan, Hon Cheung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376300/
https://www.ncbi.nlm.nih.gov/pubmed/25848330
http://dx.doi.org/10.2147/JBM.S67664
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author Chakraborty, Rajshekhar
Mukkamalla, Shiva Kumar Reddy
Gutzmore, Garfield
Chan, Hon Cheung
author_facet Chakraborty, Rajshekhar
Mukkamalla, Shiva Kumar Reddy
Gutzmore, Garfield
Chan, Hon Cheung
author_sort Chakraborty, Rajshekhar
collection PubMed
description Hodgkin’s lymphoma (HL) originates from clonal B cells and is the most common malignancy in the second decade of life. Liver involvement is uncommon at presentation in patients with HL and there is a paucity of data for treatment of patients with severely impaired liver function. We present an unusual case of HL with severe hepatic impairment, splenomegaly and multiple chromosomal abnormalities that was treated initially with gemcitabine and steroids. Once liver function tests improved, six cycles of Adriamycin, bleomycin, vinblastine, and dacarbazine were administered. The patient remains in remission at 3.5 years of follow-up.
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spelling pubmed-43763002015-04-06 A case of Hodgkin’s lymphoma with severely impaired liver function treated successfully with gemcitabine followed by ABVD Chakraborty, Rajshekhar Mukkamalla, Shiva Kumar Reddy Gutzmore, Garfield Chan, Hon Cheung J Blood Med Case Report Hodgkin’s lymphoma (HL) originates from clonal B cells and is the most common malignancy in the second decade of life. Liver involvement is uncommon at presentation in patients with HL and there is a paucity of data for treatment of patients with severely impaired liver function. We present an unusual case of HL with severe hepatic impairment, splenomegaly and multiple chromosomal abnormalities that was treated initially with gemcitabine and steroids. Once liver function tests improved, six cycles of Adriamycin, bleomycin, vinblastine, and dacarbazine were administered. The patient remains in remission at 3.5 years of follow-up. Dove Medical Press 2015-03-23 /pmc/articles/PMC4376300/ /pubmed/25848330 http://dx.doi.org/10.2147/JBM.S67664 Text en © 2015 Chakraborty et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Case Report
Chakraborty, Rajshekhar
Mukkamalla, Shiva Kumar Reddy
Gutzmore, Garfield
Chan, Hon Cheung
A case of Hodgkin’s lymphoma with severely impaired liver function treated successfully with gemcitabine followed by ABVD
title A case of Hodgkin’s lymphoma with severely impaired liver function treated successfully with gemcitabine followed by ABVD
title_full A case of Hodgkin’s lymphoma with severely impaired liver function treated successfully with gemcitabine followed by ABVD
title_fullStr A case of Hodgkin’s lymphoma with severely impaired liver function treated successfully with gemcitabine followed by ABVD
title_full_unstemmed A case of Hodgkin’s lymphoma with severely impaired liver function treated successfully with gemcitabine followed by ABVD
title_short A case of Hodgkin’s lymphoma with severely impaired liver function treated successfully with gemcitabine followed by ABVD
title_sort case of hodgkin’s lymphoma with severely impaired liver function treated successfully with gemcitabine followed by abvd
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376300/
https://www.ncbi.nlm.nih.gov/pubmed/25848330
http://dx.doi.org/10.2147/JBM.S67664
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