Cargando…

Molecular signatures of cell cycle transcripts in the pathogenesis of Glial tumors

BACKGROUND: Astrocytic brain tumors are among the most lethal and morbid tumors of adults, often occurring during the prime of life. These tumors form an interesting group of cancer to understand the molecular mechanism of pathogenesis. Histological grading of Astrocytoma based on WHO classification...

Descripción completa

Detalles Bibliográficos
Autores principales: Pillai, Anitha A, Bhattacharya, Rabindra Narayan, Radhakrishnan, Vishnampet V, Banerjee, Moinak
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC437637/
https://www.ncbi.nlm.nih.gov/pubmed/15202940
http://dx.doi.org/10.1186/1477-3163-3-11
_version_ 1782121531904622592
author Pillai, Anitha A
Bhattacharya, Rabindra Narayan
Radhakrishnan, Vishnampet V
Banerjee, Moinak
author_facet Pillai, Anitha A
Bhattacharya, Rabindra Narayan
Radhakrishnan, Vishnampet V
Banerjee, Moinak
author_sort Pillai, Anitha A
collection PubMed
description BACKGROUND: Astrocytic brain tumors are among the most lethal and morbid tumors of adults, often occurring during the prime of life. These tumors form an interesting group of cancer to understand the molecular mechanism of pathogenesis. Histological grading of Astrocytoma based on WHO classification does not provide complete information on the proliferation potential and biological behavior of the tumors. It is known that cancer results from the disruption of the orderly regulated cycle of replication and division. In the present study, we made an attempt to identify the cell cycle signatures and their involvement in the clinical aggressiveness of gliomas. METHODS: The variation in expression of various cell cycle genes was studied in different stages of glial tumor progression (low and high grades), and the results were compared with their corresponding expression levels in the normal brain tissue. Macroarray analysis was used for the purpose. RESULTS: Macroarray analysis of 114 cell cycle genes in different grades of glioma indicated differential expression pattern in 34% of the gene transcripts, when compared to the normal tissue. Majority of the transcripts belong to the intracellular kinase networks, cell cycle regulating kinases, transcription factors and transcription activators. CONCLUSION: Based on the observation in the expression pattern in low grade and high grade gliomas, it can be suggested that the upregulation of cell cycle activators are seen as an early event in glioma; however, in malignancy it is not the cell cycle activators alone, which are involved in tumorigenesis. Understanding the molecular details of cell cycle regulation and checkpoint abnormalities in cancer could offer an insight into potential therapeutic strategies.
format Text
id pubmed-437637
institution National Center for Biotechnology Information
language English
publishDate 2004
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-4376372004-06-27 Molecular signatures of cell cycle transcripts in the pathogenesis of Glial tumors Pillai, Anitha A Bhattacharya, Rabindra Narayan Radhakrishnan, Vishnampet V Banerjee, Moinak J Carcinog Short Paper BACKGROUND: Astrocytic brain tumors are among the most lethal and morbid tumors of adults, often occurring during the prime of life. These tumors form an interesting group of cancer to understand the molecular mechanism of pathogenesis. Histological grading of Astrocytoma based on WHO classification does not provide complete information on the proliferation potential and biological behavior of the tumors. It is known that cancer results from the disruption of the orderly regulated cycle of replication and division. In the present study, we made an attempt to identify the cell cycle signatures and their involvement in the clinical aggressiveness of gliomas. METHODS: The variation in expression of various cell cycle genes was studied in different stages of glial tumor progression (low and high grades), and the results were compared with their corresponding expression levels in the normal brain tissue. Macroarray analysis was used for the purpose. RESULTS: Macroarray analysis of 114 cell cycle genes in different grades of glioma indicated differential expression pattern in 34% of the gene transcripts, when compared to the normal tissue. Majority of the transcripts belong to the intracellular kinase networks, cell cycle regulating kinases, transcription factors and transcription activators. CONCLUSION: Based on the observation in the expression pattern in low grade and high grade gliomas, it can be suggested that the upregulation of cell cycle activators are seen as an early event in glioma; however, in malignancy it is not the cell cycle activators alone, which are involved in tumorigenesis. Understanding the molecular details of cell cycle regulation and checkpoint abnormalities in cancer could offer an insight into potential therapeutic strategies. BioMed Central 2004-06-17 /pmc/articles/PMC437637/ /pubmed/15202940 http://dx.doi.org/10.1186/1477-3163-3-11 Text en Copyright © 2004 Pillai et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
spellingShingle Short Paper
Pillai, Anitha A
Bhattacharya, Rabindra Narayan
Radhakrishnan, Vishnampet V
Banerjee, Moinak
Molecular signatures of cell cycle transcripts in the pathogenesis of Glial tumors
title Molecular signatures of cell cycle transcripts in the pathogenesis of Glial tumors
title_full Molecular signatures of cell cycle transcripts in the pathogenesis of Glial tumors
title_fullStr Molecular signatures of cell cycle transcripts in the pathogenesis of Glial tumors
title_full_unstemmed Molecular signatures of cell cycle transcripts in the pathogenesis of Glial tumors
title_short Molecular signatures of cell cycle transcripts in the pathogenesis of Glial tumors
title_sort molecular signatures of cell cycle transcripts in the pathogenesis of glial tumors
topic Short Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC437637/
https://www.ncbi.nlm.nih.gov/pubmed/15202940
http://dx.doi.org/10.1186/1477-3163-3-11
work_keys_str_mv AT pillaianithaa molecularsignaturesofcellcycletranscriptsinthepathogenesisofglialtumors
AT bhattacharyarabindranarayan molecularsignaturesofcellcycletranscriptsinthepathogenesisofglialtumors
AT radhakrishnanvishnampetv molecularsignaturesofcellcycletranscriptsinthepathogenesisofglialtumors
AT banerjeemoinak molecularsignaturesofcellcycletranscriptsinthepathogenesisofglialtumors