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The Role of BDNF, Leptin, and Catecholamines in Reward Learning in Bulimia Nervosa

BACKGROUND: A relationship between bulimia nervosa and reward-related behavior is supported by several lines of evidence. The dopaminergic dysfunctions in the processing of reward-related stimuli have been shown to be modulated by the neurotrophin brain derived neurotrophic factor (BDNF) and the hor...

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Autores principales: Homan, Philipp, Grob, Simona, Milos, Gabriella, Schnyder, Ulrich, Eckert, Anne, Lang, Undine, Hasler, Gregor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376547/
https://www.ncbi.nlm.nih.gov/pubmed/25522424
http://dx.doi.org/10.1093/ijnp/pyu092
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author Homan, Philipp
Grob, Simona
Milos, Gabriella
Schnyder, Ulrich
Eckert, Anne
Lang, Undine
Hasler, Gregor
author_facet Homan, Philipp
Grob, Simona
Milos, Gabriella
Schnyder, Ulrich
Eckert, Anne
Lang, Undine
Hasler, Gregor
author_sort Homan, Philipp
collection PubMed
description BACKGROUND: A relationship between bulimia nervosa and reward-related behavior is supported by several lines of evidence. The dopaminergic dysfunctions in the processing of reward-related stimuli have been shown to be modulated by the neurotrophin brain derived neurotrophic factor (BDNF) and the hormone leptin. METHODS: Using a randomized, double-blind, placebo-controlled, crossover design, a reward learning task was applied to study the behavior of 20 female subjects with remitted bulimia nervosa and 27 female healthy controls under placebo and catecholamine depletion with alpha-methyl-para-tyrosine (AMPT). The plasma levels of BDNF and leptin were measured twice during the placebo and the AMPT condition, immediately before and 1 hour after a standardized breakfast. RESULTS: AMPT–induced differences in plasma BDNF levels were positively correlated with the AMPT–induced differences in reward learning in the whole sample (P=.05). Across conditions, plasma brain derived neurotrophic factor levels were higher in remitted bulimia nervosa subjects compared with controls (diagnosis effect; P=.001). Plasma BDNF and leptin levels were higher in the morning before compared with after a standardized breakfast across groups and conditions (time effect; P<.0001). The plasma leptin levels were higher under catecholamine depletion compared with placebo in the whole sample (treatment effect; P=.0004). CONCLUSIONS: This study reports on preliminary findings that suggest a catecholamine-dependent association of plasma BDNF and reward learning in subjects with remitted bulimia nervosa and controls. A role of leptin in reward learning is not supported by this study. However, leptin levels were sensitive to a depletion of catecholamine stores in both remitted bulimia nervosa and controls.
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spelling pubmed-43765472015-09-01 The Role of BDNF, Leptin, and Catecholamines in Reward Learning in Bulimia Nervosa Homan, Philipp Grob, Simona Milos, Gabriella Schnyder, Ulrich Eckert, Anne Lang, Undine Hasler, Gregor Int J Neuropsychopharmacol Research Article BACKGROUND: A relationship between bulimia nervosa and reward-related behavior is supported by several lines of evidence. The dopaminergic dysfunctions in the processing of reward-related stimuli have been shown to be modulated by the neurotrophin brain derived neurotrophic factor (BDNF) and the hormone leptin. METHODS: Using a randomized, double-blind, placebo-controlled, crossover design, a reward learning task was applied to study the behavior of 20 female subjects with remitted bulimia nervosa and 27 female healthy controls under placebo and catecholamine depletion with alpha-methyl-para-tyrosine (AMPT). The plasma levels of BDNF and leptin were measured twice during the placebo and the AMPT condition, immediately before and 1 hour after a standardized breakfast. RESULTS: AMPT–induced differences in plasma BDNF levels were positively correlated with the AMPT–induced differences in reward learning in the whole sample (P=.05). Across conditions, plasma brain derived neurotrophic factor levels were higher in remitted bulimia nervosa subjects compared with controls (diagnosis effect; P=.001). Plasma BDNF and leptin levels were higher in the morning before compared with after a standardized breakfast across groups and conditions (time effect; P<.0001). The plasma leptin levels were higher under catecholamine depletion compared with placebo in the whole sample (treatment effect; P=.0004). CONCLUSIONS: This study reports on preliminary findings that suggest a catecholamine-dependent association of plasma BDNF and reward learning in subjects with remitted bulimia nervosa and controls. A role of leptin in reward learning is not supported by this study. However, leptin levels were sensitive to a depletion of catecholamine stores in both remitted bulimia nervosa and controls. Oxford University Press 2015-01-29 /pmc/articles/PMC4376547/ /pubmed/25522424 http://dx.doi.org/10.1093/ijnp/pyu092 Text en © The Author 2015. Published by Oxford University Press on behalf of CINP. http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Research Article
Homan, Philipp
Grob, Simona
Milos, Gabriella
Schnyder, Ulrich
Eckert, Anne
Lang, Undine
Hasler, Gregor
The Role of BDNF, Leptin, and Catecholamines in Reward Learning in Bulimia Nervosa
title The Role of BDNF, Leptin, and Catecholamines in Reward Learning in Bulimia Nervosa
title_full The Role of BDNF, Leptin, and Catecholamines in Reward Learning in Bulimia Nervosa
title_fullStr The Role of BDNF, Leptin, and Catecholamines in Reward Learning in Bulimia Nervosa
title_full_unstemmed The Role of BDNF, Leptin, and Catecholamines in Reward Learning in Bulimia Nervosa
title_short The Role of BDNF, Leptin, and Catecholamines in Reward Learning in Bulimia Nervosa
title_sort role of bdnf, leptin, and catecholamines in reward learning in bulimia nervosa
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376547/
https://www.ncbi.nlm.nih.gov/pubmed/25522424
http://dx.doi.org/10.1093/ijnp/pyu092
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