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Identification of an ADAM17 Cleavage Region in Human CD16 (FcγRIII) and the Engineering of a Non-Cleavable Version of the Receptor in NK Cells

CD16a and CD16b are IgG Fc receptors expressed by human natural killer (NK) cells and neutrophils, respectively. Both CD16 isoforms undergo a rapid down-regulation in expression by ADAM17-mediated proteolytic cleavage upon cell activation by various stimuli. We examined soluble CD16 released from ac...

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Detalles Bibliográficos
Autores principales:	Jing, Yawu, Ni, Zhenya, Wu, Jianming, Higgins, LeeAnn, Markowski, Todd W., Kaufman, Dan S., Walcheck, Bruce
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376770/ https://www.ncbi.nlm.nih.gov/pubmed/25816339 http://dx.doi.org/10.1371/journal.pone.0121788

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