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Tumor Necrosis Factor Disrupts Claudin-5 Endothelial Tight Junction Barriers in Two Distinct NF-κB-Dependent Phases

Capillary leak in severe sepsis involves disruption of endothelial cell tight junctions. We modeled this process by TNF treatment of cultured human dermal microvascular endothelial cell (HDMEC) monolayers, which unlike human umbilical vein endothelial cells form claudin-5-dependent tight junctions a...

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Detalles Bibliográficos
Autores principales:	Clark, Paul R., Kim, Richard K., Pober, Jordan S., Kluger, Martin S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376850/ https://www.ncbi.nlm.nih.gov/pubmed/25816133 http://dx.doi.org/10.1371/journal.pone.0120075

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