Concerted Activity of IgG1 Antibodies and IL-4/IL-25-Dependent Effector Cells Trap Helminth Larvae in the Tissues following Vaccination with Defined Secreted Antigens, Providing Sterile Immunity to Challenge Infection

Over 25% of the world's population are infected with helminth parasites, the majority of which colonise the gastrointestinal tract. However, no vaccine is yet available for human use, and mechanisms of protective immunity remain unclear. In the mouse model of Heligmosomoides polygyrus infection...

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Detalles Bibliográficos
Autores principales: Hewitson, James P., Filbey, Kara J., Esser-von Bieren, Julia, Camberis, Mali, Schwartz, Christian, Murray, Janice, Reynolds, Lisa A., Blair, Natalie, Robertson, Elaine, Harcus, Yvonne, Boon, Louis, Huang, Stanley Ching-Cheng, Yang, Lihua, Tu, Yizheng, Miller, Mark J., Voehringer, David, Le Gros, Graham, Harris, Nicola, Maizels, Rick M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376884/
https://www.ncbi.nlm.nih.gov/pubmed/25816012
http://dx.doi.org/10.1371/journal.ppat.1004676

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