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Mismatch Repair-Deficient Crypt Foci in Lynch Syndrome – Molecular Alterations and Association with Clinical Parameters

Lynch syndrome is caused by germline mutations of DNA mismatch repair (MMR) genes, most frequently MLH1 and MSH2. Recently, MMR-deficient crypt foci (MMR-DCF) have been identified as a novel lesion which occurs at high frequency in the intestinal mucosa from Lynch syndrome mutation carriers, but ver...

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Detalles Bibliográficos
Autores principales:	Staffa, Laura, Echterdiek, Fabian, Nelius, Nina, Benner, Axel, Werft, Wiebke, Lahrmann, Bernd, Grabe, Niels, Schneider, Martin, Tariverdian, Mirjam, von Knebel Doeberitz, Magnus, Bläker, Hendrik, Kloor, Matthias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376900/ https://www.ncbi.nlm.nih.gov/pubmed/25816162 http://dx.doi.org/10.1371/journal.pone.0121980

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