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Polymorphisms of the thiopurine S-methyltransferase gene among the Libyan population

BACKGROUND: Thiopurine S-methyltransferase (TPMT) is a cytosolic enzyme that catalyses the S-methylation of 6-mercaptopurine and azathioprine. Low activity phenotypes are correlated with polymorphism in the TPMT gene. Patients with low or undetectable TMPT activity could develop severe myelosuppress...

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Detalles Bibliográficos
Autores principales:	Zeglam, Hamza Ben, Benhamer, Abdrazak, Aboud, Adel, Rtemi, Haitem, Mattardi, Meftah, Saleh, Saleh Suleiman, Bashein, Abdullah, Enattah, Nabil
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Co-Action Publishing 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376936/ https://www.ncbi.nlm.nih.gov/pubmed/25819542 http://dx.doi.org/10.3402/ljm.v10.27053

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