Cargando…

BACA: bubble chArt to compare annotations

BACKGROUND: DAVID is the most popular tool for interpreting large lists of gene/proteins classically produced in high-throughput experiments. However, the use of DAVID website becomes difficult when analyzing multiple gene lists, for it does not provide an adequate visualization tool to show/compare...

Descripción completa

Detalles Bibliográficos
Autores principales: Fortino, Vittorio, Alenius, Harri, Greco, Dario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377007/
https://www.ncbi.nlm.nih.gov/pubmed/25652236
http://dx.doi.org/10.1186/s12859-015-0477-4
Descripción
Sumario:BACKGROUND: DAVID is the most popular tool for interpreting large lists of gene/proteins classically produced in high-throughput experiments. However, the use of DAVID website becomes difficult when analyzing multiple gene lists, for it does not provide an adequate visualization tool to show/compare multiple enrichment results in a concise and informative manner. RESULT: We implemented a new R-based graphical tool, BACA (Bubble chArt to Compare Annotations), which uses the DAVID web service for cross-comparing enrichment analysis results derived from multiple large gene lists. BACA is implemented in R and is freely available at the CRAN repository (http://cran.r-project.org/web/packages/BACA/). CONCLUSION: The package BACA allows R users to combine multiple annotation charts into one output graph by passing DAVID website. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12859-015-0477-4) contains supplementary material, which is available to authorized users.