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Lysine nutrition in swine and the related monogastric animals: muscle protein biosynthesis and beyond

Improving feed efficiency of pigs with dietary application of amino acids (AAs) is becoming increasingly important because this practice can not only secure the plasma AA supply for muscle growth but also protect the environment from nitrogen discharge with feces and urine. Lysine, the first limitin...

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Autores principales: Liao, Shengfa F, Wang, Taiji, Regmi, Naresh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377136/
https://www.ncbi.nlm.nih.gov/pubmed/25830085
http://dx.doi.org/10.1186/s40064-015-0927-5
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author Liao, Shengfa F
Wang, Taiji
Regmi, Naresh
author_facet Liao, Shengfa F
Wang, Taiji
Regmi, Naresh
author_sort Liao, Shengfa F
collection PubMed
description Improving feed efficiency of pigs with dietary application of amino acids (AAs) is becoming increasingly important because this practice can not only secure the plasma AA supply for muscle growth but also protect the environment from nitrogen discharge with feces and urine. Lysine, the first limiting AA in typical swine diets, is a substrate for generating body proteins, peptides, and non-peptide molecules, while excess lysine is catabolized as an energy source. From a regulatory standpoint, lysine is at the top level in controlling AA metabolism, and lysine can also affect the metabolism of other nutrients. The effect of lysine on hormone production and activities is reflected by the change of plasma concentrations of insulin and insulin-like growth factor 1. Lysine residues in peptides are important sites for protein post-translational modification involved in epigenetic regulation of gene expression. An inborn error of a cationic AA transporter in humans can lead to a lysinuric protein intolerance condition. Dietary deficiency of lysine will impair animal immunity and elevate animal susceptibility to infectious diseases. Because lysine deficiency has negative impact on animal health and growth performance and it appears that dietary lysine is non-toxic even at a high dose of supplementation, nutritional emphasis should be put on lysine supplementation to avoid its deficiency rather than toxicity. Improvement of muscle growth of monogastric animals such as pigs via dietary lysine supply may be due to a greater increase in protein synthesis rather than a decrease in protein degradation. Nevertheless, the underlying metabolic and molecular mechanisms regarding lysine effect on muscle protein accretion merits further clarification. Future research undertaken to fully elucidate the metabolic and regulatory mechanisms of lysine nutrition could provide a sound scientific foundation necessary for developing novel nutritional strategies to enhance the muscle growth and development of meat animals.
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spelling pubmed-43771362015-03-31 Lysine nutrition in swine and the related monogastric animals: muscle protein biosynthesis and beyond Liao, Shengfa F Wang, Taiji Regmi, Naresh Springerplus Review Improving feed efficiency of pigs with dietary application of amino acids (AAs) is becoming increasingly important because this practice can not only secure the plasma AA supply for muscle growth but also protect the environment from nitrogen discharge with feces and urine. Lysine, the first limiting AA in typical swine diets, is a substrate for generating body proteins, peptides, and non-peptide molecules, while excess lysine is catabolized as an energy source. From a regulatory standpoint, lysine is at the top level in controlling AA metabolism, and lysine can also affect the metabolism of other nutrients. The effect of lysine on hormone production and activities is reflected by the change of plasma concentrations of insulin and insulin-like growth factor 1. Lysine residues in peptides are important sites for protein post-translational modification involved in epigenetic regulation of gene expression. An inborn error of a cationic AA transporter in humans can lead to a lysinuric protein intolerance condition. Dietary deficiency of lysine will impair animal immunity and elevate animal susceptibility to infectious diseases. Because lysine deficiency has negative impact on animal health and growth performance and it appears that dietary lysine is non-toxic even at a high dose of supplementation, nutritional emphasis should be put on lysine supplementation to avoid its deficiency rather than toxicity. Improvement of muscle growth of monogastric animals such as pigs via dietary lysine supply may be due to a greater increase in protein synthesis rather than a decrease in protein degradation. Nevertheless, the underlying metabolic and molecular mechanisms regarding lysine effect on muscle protein accretion merits further clarification. Future research undertaken to fully elucidate the metabolic and regulatory mechanisms of lysine nutrition could provide a sound scientific foundation necessary for developing novel nutritional strategies to enhance the muscle growth and development of meat animals. Springer International Publishing 2015-03-27 /pmc/articles/PMC4377136/ /pubmed/25830085 http://dx.doi.org/10.1186/s40064-015-0927-5 Text en © Liao et al.; licensee Springer. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Review
Liao, Shengfa F
Wang, Taiji
Regmi, Naresh
Lysine nutrition in swine and the related monogastric animals: muscle protein biosynthesis and beyond
title Lysine nutrition in swine and the related monogastric animals: muscle protein biosynthesis and beyond
title_full Lysine nutrition in swine and the related monogastric animals: muscle protein biosynthesis and beyond
title_fullStr Lysine nutrition in swine and the related monogastric animals: muscle protein biosynthesis and beyond
title_full_unstemmed Lysine nutrition in swine and the related monogastric animals: muscle protein biosynthesis and beyond
title_short Lysine nutrition in swine and the related monogastric animals: muscle protein biosynthesis and beyond
title_sort lysine nutrition in swine and the related monogastric animals: muscle protein biosynthesis and beyond
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377136/
https://www.ncbi.nlm.nih.gov/pubmed/25830085
http://dx.doi.org/10.1186/s40064-015-0927-5
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