Cargando…
Spatial clustering of measles cases during endemic (1998–2002) and epidemic (2010) periods in Lusaka, Zambia
BACKGROUND: Measles cases may cluster in densely populated urban centers in sub-Saharan Africa as susceptible individuals share spatially dependent risk factors and may cluster among human immunodeficiency virus (HIV)-infected children despite high vaccination coverage. METHODS: Children hospitalize...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377180/ https://www.ncbi.nlm.nih.gov/pubmed/25888228 http://dx.doi.org/10.1186/s12879-015-0842-y |
_version_ | 1782363860983873536 |
---|---|
author | Pinchoff, Jessie Chipeta, James Banda, Gibson Chitundu Miti, Samuel Shields, Timothy Curriero, Frank Moss, William John |
author_facet | Pinchoff, Jessie Chipeta, James Banda, Gibson Chitundu Miti, Samuel Shields, Timothy Curriero, Frank Moss, William John |
author_sort | Pinchoff, Jessie |
collection | PubMed |
description | BACKGROUND: Measles cases may cluster in densely populated urban centers in sub-Saharan Africa as susceptible individuals share spatially dependent risk factors and may cluster among human immunodeficiency virus (HIV)-infected children despite high vaccination coverage. METHODS: Children hospitalized with measles at the University Teaching Hospital (UTH) in Lusaka, Zambia were enrolled in the study. The township of residence was recorded on the questionnaire and mapped; SaTScan software was used for cluster detection. A spatial-temporal scan statistic was used to investigate clustering of measles in children hospitalized during an endemic period (1998 to 2002) and during the 2010 measles outbreak in Lusaka, Zambia. RESULTS: Three sequential and spatially contiguous clusters of measles cases were identified during the 2010 outbreak but no clustering among HIV-infected children was identified. In contrast, a space-time cluster among HIV-infected children was identified during the endemic period. This cluster occurred prior to the introduction of intensive measles control efforts and during a period between seasonal peaks in measles incidence. CONCLUSIONS: Prediction and early identification of spatial clusters of measles will be critical to achieving measles elimination. HIV infection may contribute to spatial clustering of measles cases in some epidemiological settings. |
format | Online Article Text |
id | pubmed-4377180 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-43771802015-03-30 Spatial clustering of measles cases during endemic (1998–2002) and epidemic (2010) periods in Lusaka, Zambia Pinchoff, Jessie Chipeta, James Banda, Gibson Chitundu Miti, Samuel Shields, Timothy Curriero, Frank Moss, William John BMC Infect Dis Research Article BACKGROUND: Measles cases may cluster in densely populated urban centers in sub-Saharan Africa as susceptible individuals share spatially dependent risk factors and may cluster among human immunodeficiency virus (HIV)-infected children despite high vaccination coverage. METHODS: Children hospitalized with measles at the University Teaching Hospital (UTH) in Lusaka, Zambia were enrolled in the study. The township of residence was recorded on the questionnaire and mapped; SaTScan software was used for cluster detection. A spatial-temporal scan statistic was used to investigate clustering of measles in children hospitalized during an endemic period (1998 to 2002) and during the 2010 measles outbreak in Lusaka, Zambia. RESULTS: Three sequential and spatially contiguous clusters of measles cases were identified during the 2010 outbreak but no clustering among HIV-infected children was identified. In contrast, a space-time cluster among HIV-infected children was identified during the endemic period. This cluster occurred prior to the introduction of intensive measles control efforts and during a period between seasonal peaks in measles incidence. CONCLUSIONS: Prediction and early identification of spatial clusters of measles will be critical to achieving measles elimination. HIV infection may contribute to spatial clustering of measles cases in some epidemiological settings. BioMed Central 2015-03-10 /pmc/articles/PMC4377180/ /pubmed/25888228 http://dx.doi.org/10.1186/s12879-015-0842-y Text en © Pinchoff et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Pinchoff, Jessie Chipeta, James Banda, Gibson Chitundu Miti, Samuel Shields, Timothy Curriero, Frank Moss, William John Spatial clustering of measles cases during endemic (1998–2002) and epidemic (2010) periods in Lusaka, Zambia |
title | Spatial clustering of measles cases during endemic (1998–2002) and epidemic (2010) periods in Lusaka, Zambia |
title_full | Spatial clustering of measles cases during endemic (1998–2002) and epidemic (2010) periods in Lusaka, Zambia |
title_fullStr | Spatial clustering of measles cases during endemic (1998–2002) and epidemic (2010) periods in Lusaka, Zambia |
title_full_unstemmed | Spatial clustering of measles cases during endemic (1998–2002) and epidemic (2010) periods in Lusaka, Zambia |
title_short | Spatial clustering of measles cases during endemic (1998–2002) and epidemic (2010) periods in Lusaka, Zambia |
title_sort | spatial clustering of measles cases during endemic (1998–2002) and epidemic (2010) periods in lusaka, zambia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377180/ https://www.ncbi.nlm.nih.gov/pubmed/25888228 http://dx.doi.org/10.1186/s12879-015-0842-y |
work_keys_str_mv | AT pinchoffjessie spatialclusteringofmeaslescasesduringendemic19982002andepidemic2010periodsinlusakazambia AT chipetajames spatialclusteringofmeaslescasesduringendemic19982002andepidemic2010periodsinlusakazambia AT bandagibsonchitundu spatialclusteringofmeaslescasesduringendemic19982002andepidemic2010periodsinlusakazambia AT mitisamuel spatialclusteringofmeaslescasesduringendemic19982002andepidemic2010periodsinlusakazambia AT shieldstimothy spatialclusteringofmeaslescasesduringendemic19982002andepidemic2010periodsinlusakazambia AT currierofrank spatialclusteringofmeaslescasesduringendemic19982002andepidemic2010periodsinlusakazambia AT mosswilliamjohn spatialclusteringofmeaslescasesduringendemic19982002andepidemic2010periodsinlusakazambia |