Cargando…

Spatial clustering of measles cases during endemic (1998–2002) and epidemic (2010) periods in Lusaka, Zambia

BACKGROUND: Measles cases may cluster in densely populated urban centers in sub-Saharan Africa as susceptible individuals share spatially dependent risk factors and may cluster among human immunodeficiency virus (HIV)-infected children despite high vaccination coverage. METHODS: Children hospitalize...

Descripción completa

Detalles Bibliográficos
Autores principales: Pinchoff, Jessie, Chipeta, James, Banda, Gibson Chitundu, Miti, Samuel, Shields, Timothy, Curriero, Frank, Moss, William John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377180/
https://www.ncbi.nlm.nih.gov/pubmed/25888228
http://dx.doi.org/10.1186/s12879-015-0842-y
_version_ 1782363860983873536
author Pinchoff, Jessie
Chipeta, James
Banda, Gibson Chitundu
Miti, Samuel
Shields, Timothy
Curriero, Frank
Moss, William John
author_facet Pinchoff, Jessie
Chipeta, James
Banda, Gibson Chitundu
Miti, Samuel
Shields, Timothy
Curriero, Frank
Moss, William John
author_sort Pinchoff, Jessie
collection PubMed
description BACKGROUND: Measles cases may cluster in densely populated urban centers in sub-Saharan Africa as susceptible individuals share spatially dependent risk factors and may cluster among human immunodeficiency virus (HIV)-infected children despite high vaccination coverage. METHODS: Children hospitalized with measles at the University Teaching Hospital (UTH) in Lusaka, Zambia were enrolled in the study. The township of residence was recorded on the questionnaire and mapped; SaTScan software was used for cluster detection. A spatial-temporal scan statistic was used to investigate clustering of measles in children hospitalized during an endemic period (1998 to 2002) and during the 2010 measles outbreak in Lusaka, Zambia. RESULTS: Three sequential and spatially contiguous clusters of measles cases were identified during the 2010 outbreak but no clustering among HIV-infected children was identified. In contrast, a space-time cluster among HIV-infected children was identified during the endemic period. This cluster occurred prior to the introduction of intensive measles control efforts and during a period between seasonal peaks in measles incidence. CONCLUSIONS: Prediction and early identification of spatial clusters of measles will be critical to achieving measles elimination. HIV infection may contribute to spatial clustering of measles cases in some epidemiological settings.
format Online
Article
Text
id pubmed-4377180
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-43771802015-03-30 Spatial clustering of measles cases during endemic (1998–2002) and epidemic (2010) periods in Lusaka, Zambia Pinchoff, Jessie Chipeta, James Banda, Gibson Chitundu Miti, Samuel Shields, Timothy Curriero, Frank Moss, William John BMC Infect Dis Research Article BACKGROUND: Measles cases may cluster in densely populated urban centers in sub-Saharan Africa as susceptible individuals share spatially dependent risk factors and may cluster among human immunodeficiency virus (HIV)-infected children despite high vaccination coverage. METHODS: Children hospitalized with measles at the University Teaching Hospital (UTH) in Lusaka, Zambia were enrolled in the study. The township of residence was recorded on the questionnaire and mapped; SaTScan software was used for cluster detection. A spatial-temporal scan statistic was used to investigate clustering of measles in children hospitalized during an endemic period (1998 to 2002) and during the 2010 measles outbreak in Lusaka, Zambia. RESULTS: Three sequential and spatially contiguous clusters of measles cases were identified during the 2010 outbreak but no clustering among HIV-infected children was identified. In contrast, a space-time cluster among HIV-infected children was identified during the endemic period. This cluster occurred prior to the introduction of intensive measles control efforts and during a period between seasonal peaks in measles incidence. CONCLUSIONS: Prediction and early identification of spatial clusters of measles will be critical to achieving measles elimination. HIV infection may contribute to spatial clustering of measles cases in some epidemiological settings. BioMed Central 2015-03-10 /pmc/articles/PMC4377180/ /pubmed/25888228 http://dx.doi.org/10.1186/s12879-015-0842-y Text en © Pinchoff et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Pinchoff, Jessie
Chipeta, James
Banda, Gibson Chitundu
Miti, Samuel
Shields, Timothy
Curriero, Frank
Moss, William John
Spatial clustering of measles cases during endemic (1998–2002) and epidemic (2010) periods in Lusaka, Zambia
title Spatial clustering of measles cases during endemic (1998–2002) and epidemic (2010) periods in Lusaka, Zambia
title_full Spatial clustering of measles cases during endemic (1998–2002) and epidemic (2010) periods in Lusaka, Zambia
title_fullStr Spatial clustering of measles cases during endemic (1998–2002) and epidemic (2010) periods in Lusaka, Zambia
title_full_unstemmed Spatial clustering of measles cases during endemic (1998–2002) and epidemic (2010) periods in Lusaka, Zambia
title_short Spatial clustering of measles cases during endemic (1998–2002) and epidemic (2010) periods in Lusaka, Zambia
title_sort spatial clustering of measles cases during endemic (1998–2002) and epidemic (2010) periods in lusaka, zambia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377180/
https://www.ncbi.nlm.nih.gov/pubmed/25888228
http://dx.doi.org/10.1186/s12879-015-0842-y
work_keys_str_mv AT pinchoffjessie spatialclusteringofmeaslescasesduringendemic19982002andepidemic2010periodsinlusakazambia
AT chipetajames spatialclusteringofmeaslescasesduringendemic19982002andepidemic2010periodsinlusakazambia
AT bandagibsonchitundu spatialclusteringofmeaslescasesduringendemic19982002andepidemic2010periodsinlusakazambia
AT mitisamuel spatialclusteringofmeaslescasesduringendemic19982002andepidemic2010periodsinlusakazambia
AT shieldstimothy spatialclusteringofmeaslescasesduringendemic19982002andepidemic2010periodsinlusakazambia
AT currierofrank spatialclusteringofmeaslescasesduringendemic19982002andepidemic2010periodsinlusakazambia
AT mosswilliamjohn spatialclusteringofmeaslescasesduringendemic19982002andepidemic2010periodsinlusakazambia