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A rare case of anasarca caused by infiltration of the pituitary gland by diffuse large B-cell lymphoma
BACKGROUND: Anasarca in patients with lymphoma is a rare symptom. We report a patient with DLBCL associated with pituitary gland infiltration that was diagnosed based on significant anasarca. CASE PRESENTATION: A 72-year-old woman with a 10-year history of hypertension visited a local hospital prese...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377186/ https://www.ncbi.nlm.nih.gov/pubmed/25887623 http://dx.doi.org/10.1186/s12902-015-0007-4 |
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author | Kumabe, Ayako Kenzaka, Tsuneaki Nishimura, Yoshioki Aikawa, Masaki Mori, Masaki Matsumura, Masami |
author_facet | Kumabe, Ayako Kenzaka, Tsuneaki Nishimura, Yoshioki Aikawa, Masaki Mori, Masaki Matsumura, Masami |
author_sort | Kumabe, Ayako |
collection | PubMed |
description | BACKGROUND: Anasarca in patients with lymphoma is a rare symptom. We report a patient with DLBCL associated with pituitary gland infiltration that was diagnosed based on significant anasarca. CASE PRESENTATION: A 72-year-old woman with a 10-year history of hypertension visited a local hospital presenting with anasarca and 15-kg weight gain in the past 3 months. we clinically diagnosed central hypothyroidism caused by pituitary gland infiltration of diffuse large B-cell lymphoma (DLBCL) (clinical stage IV in the Ann Arbor staging classification). The first course of chemotherapy improved anasarca remarkably and the patient’s body weight returned to what it was 3 months before. CONCLUSIONS: We experienced a patient with remarkable anasarca caused by DLBCL infiltration of the pituitary gland. A pituitary gland lesion with central hypothyroidism should be considered as one of the differential diagnoses of edema. This case was very valuable because we could assess it by following the time course of symptoms (edema and delayed relaxation time of the Achilles tendon reflex), laboratory data, and imaging findings (swelling anterior pituitary lobe). |
format | Online Article Text |
id | pubmed-4377186 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-43771862015-03-30 A rare case of anasarca caused by infiltration of the pituitary gland by diffuse large B-cell lymphoma Kumabe, Ayako Kenzaka, Tsuneaki Nishimura, Yoshioki Aikawa, Masaki Mori, Masaki Matsumura, Masami BMC Endocr Disord Case Report BACKGROUND: Anasarca in patients with lymphoma is a rare symptom. We report a patient with DLBCL associated with pituitary gland infiltration that was diagnosed based on significant anasarca. CASE PRESENTATION: A 72-year-old woman with a 10-year history of hypertension visited a local hospital presenting with anasarca and 15-kg weight gain in the past 3 months. we clinically diagnosed central hypothyroidism caused by pituitary gland infiltration of diffuse large B-cell lymphoma (DLBCL) (clinical stage IV in the Ann Arbor staging classification). The first course of chemotherapy improved anasarca remarkably and the patient’s body weight returned to what it was 3 months before. CONCLUSIONS: We experienced a patient with remarkable anasarca caused by DLBCL infiltration of the pituitary gland. A pituitary gland lesion with central hypothyroidism should be considered as one of the differential diagnoses of edema. This case was very valuable because we could assess it by following the time course of symptoms (edema and delayed relaxation time of the Achilles tendon reflex), laboratory data, and imaging findings (swelling anterior pituitary lobe). BioMed Central 2015-03-25 /pmc/articles/PMC4377186/ /pubmed/25887623 http://dx.doi.org/10.1186/s12902-015-0007-4 Text en © Kumabe et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Case Report Kumabe, Ayako Kenzaka, Tsuneaki Nishimura, Yoshioki Aikawa, Masaki Mori, Masaki Matsumura, Masami A rare case of anasarca caused by infiltration of the pituitary gland by diffuse large B-cell lymphoma |
title | A rare case of anasarca caused by infiltration of the pituitary gland by diffuse large B-cell lymphoma |
title_full | A rare case of anasarca caused by infiltration of the pituitary gland by diffuse large B-cell lymphoma |
title_fullStr | A rare case of anasarca caused by infiltration of the pituitary gland by diffuse large B-cell lymphoma |
title_full_unstemmed | A rare case of anasarca caused by infiltration of the pituitary gland by diffuse large B-cell lymphoma |
title_short | A rare case of anasarca caused by infiltration of the pituitary gland by diffuse large B-cell lymphoma |
title_sort | rare case of anasarca caused by infiltration of the pituitary gland by diffuse large b-cell lymphoma |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377186/ https://www.ncbi.nlm.nih.gov/pubmed/25887623 http://dx.doi.org/10.1186/s12902-015-0007-4 |
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