A case of CLL that was successfully treated resulted in the immediate development of AML from a coexistent myeloid line that had been suppressed

An 83 year-old Caucasian male presented to the emergency room with confusion and lethargy. A complete blood count revealed lymphocytosis, anemia, and thrombocytopenia. A bone marrow examination revealed chronic lymphocytic leukemia (CLL), along with a small population of abnormal immature myeloid ce...

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Detalles Bibliográficos
Autores principales: Ansari, Mohammad, Auerbach, Michael, Bahrain, Huzefa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377248/
https://www.ncbi.nlm.nih.gov/pubmed/25838906
http://dx.doi.org/10.1002/ccr3.184
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author Ansari, Mohammad
Auerbach, Michael
Bahrain, Huzefa
author_facet Ansari, Mohammad
Auerbach, Michael
Bahrain, Huzefa
author_sort Ansari, Mohammad
collection PubMed
description An 83 year-old Caucasian male presented to the emergency room with confusion and lethargy. A complete blood count revealed lymphocytosis, anemia, and thrombocytopenia. A bone marrow examination revealed chronic lymphocytic leukemia (CLL), along with a small population of abnormal immature myeloid cells. Chemotherapy for CLL was started. After one cycle, repeat bone marrow examination revealed normalization of the lymphocyte count and a proliferation of the previously noted myeloid population, consistent with acute myeloid leukemia (AML). This report presents the microscopic, immunophenotypic, and cytogenetic evidence to document the development of AML after one cycle of chemotherapy for CLL.
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spelling pubmed-43772482015-04-02 A case of CLL that was successfully treated resulted in the immediate development of AML from a coexistent myeloid line that had been suppressed Ansari, Mohammad Auerbach, Michael Bahrain, Huzefa Clin Case Rep Case Reports An 83 year-old Caucasian male presented to the emergency room with confusion and lethargy. A complete blood count revealed lymphocytosis, anemia, and thrombocytopenia. A bone marrow examination revealed chronic lymphocytic leukemia (CLL), along with a small population of abnormal immature myeloid cells. Chemotherapy for CLL was started. After one cycle, repeat bone marrow examination revealed normalization of the lymphocyte count and a proliferation of the previously noted myeloid population, consistent with acute myeloid leukemia (AML). This report presents the microscopic, immunophenotypic, and cytogenetic evidence to document the development of AML after one cycle of chemotherapy for CLL. BlackWell Publishing Ltd 2015-03 2014-12-22 /pmc/articles/PMC4377248/ /pubmed/25838906 http://dx.doi.org/10.1002/ccr3.184 Text en © 2014 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Case Reports
Ansari, Mohammad
Auerbach, Michael
Bahrain, Huzefa
A case of CLL that was successfully treated resulted in the immediate development of AML from a coexistent myeloid line that had been suppressed
title A case of CLL that was successfully treated resulted in the immediate development of AML from a coexistent myeloid line that had been suppressed
title_full A case of CLL that was successfully treated resulted in the immediate development of AML from a coexistent myeloid line that had been suppressed
title_fullStr A case of CLL that was successfully treated resulted in the immediate development of AML from a coexistent myeloid line that had been suppressed
title_full_unstemmed A case of CLL that was successfully treated resulted in the immediate development of AML from a coexistent myeloid line that had been suppressed
title_short A case of CLL that was successfully treated resulted in the immediate development of AML from a coexistent myeloid line that had been suppressed
title_sort case of cll that was successfully treated resulted in the immediate development of aml from a coexistent myeloid line that had been suppressed
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377248/
https://www.ncbi.nlm.nih.gov/pubmed/25838906
http://dx.doi.org/10.1002/ccr3.184
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