Fulminant onset of acute leukemia from normal hematopoiesis within 3 months of follow up for multiple myeloma treated with total therapy protocols

Assiduous surveillance for genetic aberrations is necessary in patients on cytotoxic therapies to detect therapy-related myeloid neoplasms (t-MN). Current modalities include metaphase cytogenetics and FISH. Since t-MN may develop abruptly in cytogenetically normal patients, a discussion exploring ad...

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Autores principales: Singh, Zeba N, Jethava, Yogesh, Post, Ginell R, Alapat, Daisy, Sawyer, Jeffrey, Waheed, Sarah, Nair, Bijay, Usmani, Saad Z, Bailey, Clyde, Petty, Nathan, Van Rhee, Frits, Barlogie, Bart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377252/
https://www.ncbi.nlm.nih.gov/pubmed/25838910
http://dx.doi.org/10.1002/ccr3.180
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author Singh, Zeba N
Jethava, Yogesh
Post, Ginell R
Alapat, Daisy
Sawyer, Jeffrey
Waheed, Sarah
Nair, Bijay
Usmani, Saad Z
Bailey, Clyde
Petty, Nathan
Van Rhee, Frits
Barlogie, Bart
author_facet Singh, Zeba N
Jethava, Yogesh
Post, Ginell R
Alapat, Daisy
Sawyer, Jeffrey
Waheed, Sarah
Nair, Bijay
Usmani, Saad Z
Bailey, Clyde
Petty, Nathan
Van Rhee, Frits
Barlogie, Bart
author_sort Singh, Zeba N
collection PubMed
description Assiduous surveillance for genetic aberrations is necessary in patients on cytotoxic therapies to detect therapy-related myeloid neoplasms (t-MN). Current modalities include metaphase cytogenetics and FISH. Since t-MN may develop abruptly in cytogenetically normal patients, a discussion exploring additional methods such as SNP-array and targeted-deep-sequencing to detect subchromosomal abnormalities is needed.
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spelling pubmed-43772522015-04-02 Fulminant onset of acute leukemia from normal hematopoiesis within 3 months of follow up for multiple myeloma treated with total therapy protocols Singh, Zeba N Jethava, Yogesh Post, Ginell R Alapat, Daisy Sawyer, Jeffrey Waheed, Sarah Nair, Bijay Usmani, Saad Z Bailey, Clyde Petty, Nathan Van Rhee, Frits Barlogie, Bart Clin Case Rep Case Reports Assiduous surveillance for genetic aberrations is necessary in patients on cytotoxic therapies to detect therapy-related myeloid neoplasms (t-MN). Current modalities include metaphase cytogenetics and FISH. Since t-MN may develop abruptly in cytogenetically normal patients, a discussion exploring additional methods such as SNP-array and targeted-deep-sequencing to detect subchromosomal abnormalities is needed. BlackWell Publishing Ltd 2015-03 2015-02-13 /pmc/articles/PMC4377252/ /pubmed/25838910 http://dx.doi.org/10.1002/ccr3.180 Text en © 2015 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Case Reports
Singh, Zeba N
Jethava, Yogesh
Post, Ginell R
Alapat, Daisy
Sawyer, Jeffrey
Waheed, Sarah
Nair, Bijay
Usmani, Saad Z
Bailey, Clyde
Petty, Nathan
Van Rhee, Frits
Barlogie, Bart
Fulminant onset of acute leukemia from normal hematopoiesis within 3 months of follow up for multiple myeloma treated with total therapy protocols
title Fulminant onset of acute leukemia from normal hematopoiesis within 3 months of follow up for multiple myeloma treated with total therapy protocols
title_full Fulminant onset of acute leukemia from normal hematopoiesis within 3 months of follow up for multiple myeloma treated with total therapy protocols
title_fullStr Fulminant onset of acute leukemia from normal hematopoiesis within 3 months of follow up for multiple myeloma treated with total therapy protocols
title_full_unstemmed Fulminant onset of acute leukemia from normal hematopoiesis within 3 months of follow up for multiple myeloma treated with total therapy protocols
title_short Fulminant onset of acute leukemia from normal hematopoiesis within 3 months of follow up for multiple myeloma treated with total therapy protocols
title_sort fulminant onset of acute leukemia from normal hematopoiesis within 3 months of follow up for multiple myeloma treated with total therapy protocols
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377252/
https://www.ncbi.nlm.nih.gov/pubmed/25838910
http://dx.doi.org/10.1002/ccr3.180
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