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Transcriptional repression of Sin3B by Bmi-1 prevents cellular senescence and is relieved by oncogene activation
The Polycomb group protein Bmi-1 is an essential regulator of cellular senescence and is believed to function largely through the direct repression of the Ink4a/Arf locus. However, concurrent deletion of Ink4a/Arf does not fully rescue the defects detected in Bmi-1(−/−) mice, indicating that additio...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377314/ https://www.ncbi.nlm.nih.gov/pubmed/25263442 http://dx.doi.org/10.1038/onc.2014.322 |