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In Vitro Antimicrobial and Modulatory Activity of the Natural Products Silymarin and Silibinin
Silymarin is a standardized extract from the dried seeds of the milk thistle (Silybum marianum L. Gaertn.) clinically used as an antihepatotoxic agent. The aim of this study was to investigate the antibacterial and antifungal activity of silymarin and its major constituent (silibinin) against differ...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377387/ https://www.ncbi.nlm.nih.gov/pubmed/25866771 http://dx.doi.org/10.1155/2015/292797 |
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author | Rakelly de Oliveira, Dayanne Relison Tintino, Saulo Morais Braga, Maria Flaviana Bezerra Boligon, Aline Augusti Linde Athayde, Margareth Douglas Melo Coutinho, Henrique de Menezes, Irwin Rose Alencar Fachinetto, Roselei |
author_facet | Rakelly de Oliveira, Dayanne Relison Tintino, Saulo Morais Braga, Maria Flaviana Bezerra Boligon, Aline Augusti Linde Athayde, Margareth Douglas Melo Coutinho, Henrique de Menezes, Irwin Rose Alencar Fachinetto, Roselei |
author_sort | Rakelly de Oliveira, Dayanne |
collection | PubMed |
description | Silymarin is a standardized extract from the dried seeds of the milk thistle (Silybum marianum L. Gaertn.) clinically used as an antihepatotoxic agent. The aim of this study was to investigate the antibacterial and antifungal activity of silymarin and its major constituent (silibinin) against different microbial strains and their modulatory effect on drugs utilized in clinical practice. Silymarin demonstrated antimicrobial activity of little significance against the bacterial strains tested, with MIC (minimum inhibitory concentration) values of 512 µg/mL. Meanwhile, silibinin showed significant activity against Escherichia coli with a MIC of 64 µg/mL. The results for the antifungal activity of silymarin and silibinin demonstrated a MIC of 1024 µg/mL for all strains. Silymarin and silibinin appear to have promising potential, showing synergistic properties when combined with antibacterial drugs, which should prompt further studies along this line. |
format | Online Article Text |
id | pubmed-4377387 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-43773872015-04-12 In Vitro Antimicrobial and Modulatory Activity of the Natural Products Silymarin and Silibinin Rakelly de Oliveira, Dayanne Relison Tintino, Saulo Morais Braga, Maria Flaviana Bezerra Boligon, Aline Augusti Linde Athayde, Margareth Douglas Melo Coutinho, Henrique de Menezes, Irwin Rose Alencar Fachinetto, Roselei Biomed Res Int Research Article Silymarin is a standardized extract from the dried seeds of the milk thistle (Silybum marianum L. Gaertn.) clinically used as an antihepatotoxic agent. The aim of this study was to investigate the antibacterial and antifungal activity of silymarin and its major constituent (silibinin) against different microbial strains and their modulatory effect on drugs utilized in clinical practice. Silymarin demonstrated antimicrobial activity of little significance against the bacterial strains tested, with MIC (minimum inhibitory concentration) values of 512 µg/mL. Meanwhile, silibinin showed significant activity against Escherichia coli with a MIC of 64 µg/mL. The results for the antifungal activity of silymarin and silibinin demonstrated a MIC of 1024 µg/mL for all strains. Silymarin and silibinin appear to have promising potential, showing synergistic properties when combined with antibacterial drugs, which should prompt further studies along this line. Hindawi Publishing Corporation 2015 2015-03-11 /pmc/articles/PMC4377387/ /pubmed/25866771 http://dx.doi.org/10.1155/2015/292797 Text en Copyright © 2015 Dayanne Rakelly de Oliveira et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Rakelly de Oliveira, Dayanne Relison Tintino, Saulo Morais Braga, Maria Flaviana Bezerra Boligon, Aline Augusti Linde Athayde, Margareth Douglas Melo Coutinho, Henrique de Menezes, Irwin Rose Alencar Fachinetto, Roselei In Vitro Antimicrobial and Modulatory Activity of the Natural Products Silymarin and Silibinin |
title |
In Vitro Antimicrobial and Modulatory Activity of the Natural Products Silymarin and Silibinin |
title_full |
In Vitro Antimicrobial and Modulatory Activity of the Natural Products Silymarin and Silibinin |
title_fullStr |
In Vitro Antimicrobial and Modulatory Activity of the Natural Products Silymarin and Silibinin |
title_full_unstemmed |
In Vitro Antimicrobial and Modulatory Activity of the Natural Products Silymarin and Silibinin |
title_short |
In Vitro Antimicrobial and Modulatory Activity of the Natural Products Silymarin and Silibinin |
title_sort | in vitro antimicrobial and modulatory activity of the natural products silymarin and silibinin |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377387/ https://www.ncbi.nlm.nih.gov/pubmed/25866771 http://dx.doi.org/10.1155/2015/292797 |
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