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Management of Pruritus in Chronic Liver Disease

Background. There continues to be uncertainty on the ideal treatment of pruritus in chronic liver disease. The aim of this study was to gather the latest information on the evidence-based management of pruritus in chronic liver disease. Methodology. A literature search for pruritus in chronic liver...

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Detalles Bibliográficos
Autores principales: Bhalerao, Angeline, Mannu, Gurdeep S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377431/
https://www.ncbi.nlm.nih.gov/pubmed/25861254
http://dx.doi.org/10.1155/2015/295891
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author Bhalerao, Angeline
Mannu, Gurdeep S.
author_facet Bhalerao, Angeline
Mannu, Gurdeep S.
author_sort Bhalerao, Angeline
collection PubMed
description Background. There continues to be uncertainty on the ideal treatment of pruritus in chronic liver disease. The aim of this study was to gather the latest information on the evidence-based management of pruritus in chronic liver disease. Methodology. A literature search for pruritus in chronic liver disease was conducted using Pubmed and Embase database systems using the MeSH terms “pruritus,” “chronic liver disease,” “cholestatic liver disease,” and “treatment.” Results. The current understanding of the pathophysiology of pruritus is described in addition to detailing research into contemporary treatment options of the condition. These medical treatments range from bile salts, rifampicin, and opioid receptor antagonists to antihistamines. Conclusion. The burden of pruritus in liver disease patients persists and, although it is a common symptom, it can be difficult to manage. In recent years there has been greater study into the etiology and treatment of the condition. Nonetheless, pruritus remains poorly understood and many patients continue to suffer, reiterating the need for further research to improve our understanding of the etiology and treatment for the condition.
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spelling pubmed-43774312015-04-08 Management of Pruritus in Chronic Liver Disease Bhalerao, Angeline Mannu, Gurdeep S. Dermatol Res Pract Review Article Background. There continues to be uncertainty on the ideal treatment of pruritus in chronic liver disease. The aim of this study was to gather the latest information on the evidence-based management of pruritus in chronic liver disease. Methodology. A literature search for pruritus in chronic liver disease was conducted using Pubmed and Embase database systems using the MeSH terms “pruritus,” “chronic liver disease,” “cholestatic liver disease,” and “treatment.” Results. The current understanding of the pathophysiology of pruritus is described in addition to detailing research into contemporary treatment options of the condition. These medical treatments range from bile salts, rifampicin, and opioid receptor antagonists to antihistamines. Conclusion. The burden of pruritus in liver disease patients persists and, although it is a common symptom, it can be difficult to manage. In recent years there has been greater study into the etiology and treatment of the condition. Nonetheless, pruritus remains poorly understood and many patients continue to suffer, reiterating the need for further research to improve our understanding of the etiology and treatment for the condition. Hindawi Publishing Corporation 2015 2015-03-10 /pmc/articles/PMC4377431/ /pubmed/25861254 http://dx.doi.org/10.1155/2015/295891 Text en Copyright © 2015 A. Bhalerao and G. S. Mannu. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Bhalerao, Angeline
Mannu, Gurdeep S.
Management of Pruritus in Chronic Liver Disease
title Management of Pruritus in Chronic Liver Disease
title_full Management of Pruritus in Chronic Liver Disease
title_fullStr Management of Pruritus in Chronic Liver Disease
title_full_unstemmed Management of Pruritus in Chronic Liver Disease
title_short Management of Pruritus in Chronic Liver Disease
title_sort management of pruritus in chronic liver disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377431/
https://www.ncbi.nlm.nih.gov/pubmed/25861254
http://dx.doi.org/10.1155/2015/295891
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