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Decreased Perifoveal Sensitivity Detected by Microperimetry in Patients Using Hydroxychloroquine and without Visual Field and Fundoscopic Anomalies
Purpose. To evaluate the usefulness of microperimetry in the early detection of the ocular anomalies associated with the use of hydroxychloroquine. Methods. Prospective comparative case series study comprising 14 healthy eyes of 7 patients (group A) and 14 eyes of 7 patients under treatment with hyd...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377466/ https://www.ncbi.nlm.nih.gov/pubmed/25861463 http://dx.doi.org/10.1155/2015/437271 |
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author | Molina-Martín, A. Piñero, D. P. Pérez-Cambrodí, R. J. |
author_facet | Molina-Martín, A. Piñero, D. P. Pérez-Cambrodí, R. J. |
author_sort | Molina-Martín, A. |
collection | PubMed |
description | Purpose. To evaluate the usefulness of microperimetry in the early detection of the ocular anomalies associated with the use of hydroxychloroquine. Methods. Prospective comparative case series study comprising 14 healthy eyes of 7 patients (group A) and 14 eyes of 7 patients under treatment with hydroxychloroquine for the treatment of rheumatologic diseases and without fundoscopic or perimetric anomalies (group B). A comprehensive ophthalmological examination including microperimetry (MP) and spectral-domain optical coherence tomography was performed in both groups. Results. No significant differences were found in mean MP foveal sensitivity between groups (P = 0.18). However, mean MP overall sensitivity was significantly higher in group A (29.05 ± 0.57 dB versus group B, 26.05 ± 2.75 dB; P < 0.001). Significantly higher sensitivity values were obtained in group A in comparison to group B for the three eccentric loci evaluated (P < 0.001). Conclusion. Microperimetry seems to be a useful tool for the early detection of retinal damage in patients treated with hydroxychloroquine. |
format | Online Article Text |
id | pubmed-4377466 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-43774662015-04-08 Decreased Perifoveal Sensitivity Detected by Microperimetry in Patients Using Hydroxychloroquine and without Visual Field and Fundoscopic Anomalies Molina-Martín, A. Piñero, D. P. Pérez-Cambrodí, R. J. J Ophthalmol Research Article Purpose. To evaluate the usefulness of microperimetry in the early detection of the ocular anomalies associated with the use of hydroxychloroquine. Methods. Prospective comparative case series study comprising 14 healthy eyes of 7 patients (group A) and 14 eyes of 7 patients under treatment with hydroxychloroquine for the treatment of rheumatologic diseases and without fundoscopic or perimetric anomalies (group B). A comprehensive ophthalmological examination including microperimetry (MP) and spectral-domain optical coherence tomography was performed in both groups. Results. No significant differences were found in mean MP foveal sensitivity between groups (P = 0.18). However, mean MP overall sensitivity was significantly higher in group A (29.05 ± 0.57 dB versus group B, 26.05 ± 2.75 dB; P < 0.001). Significantly higher sensitivity values were obtained in group A in comparison to group B for the three eccentric loci evaluated (P < 0.001). Conclusion. Microperimetry seems to be a useful tool for the early detection of retinal damage in patients treated with hydroxychloroquine. Hindawi Publishing Corporation 2015 2015-03-12 /pmc/articles/PMC4377466/ /pubmed/25861463 http://dx.doi.org/10.1155/2015/437271 Text en Copyright © 2015 A. Molina-Martín et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Molina-Martín, A. Piñero, D. P. Pérez-Cambrodí, R. J. Decreased Perifoveal Sensitivity Detected by Microperimetry in Patients Using Hydroxychloroquine and without Visual Field and Fundoscopic Anomalies |
title | Decreased Perifoveal Sensitivity Detected by Microperimetry in
Patients Using Hydroxychloroquine and without Visual Field and Fundoscopic Anomalies |
title_full | Decreased Perifoveal Sensitivity Detected by Microperimetry in
Patients Using Hydroxychloroquine and without Visual Field and Fundoscopic Anomalies |
title_fullStr | Decreased Perifoveal Sensitivity Detected by Microperimetry in
Patients Using Hydroxychloroquine and without Visual Field and Fundoscopic Anomalies |
title_full_unstemmed | Decreased Perifoveal Sensitivity Detected by Microperimetry in
Patients Using Hydroxychloroquine and without Visual Field and Fundoscopic Anomalies |
title_short | Decreased Perifoveal Sensitivity Detected by Microperimetry in
Patients Using Hydroxychloroquine and without Visual Field and Fundoscopic Anomalies |
title_sort | decreased perifoveal sensitivity detected by microperimetry in
patients using hydroxychloroquine and without visual field and fundoscopic anomalies |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377466/ https://www.ncbi.nlm.nih.gov/pubmed/25861463 http://dx.doi.org/10.1155/2015/437271 |
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