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HIV Vaccine Research: The Challenge and the Way Forward

Human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) is a worldwide epidemic, with over 35 million people infected currently. Therefore, the development of a safe and effective HIV-1 vaccine is on top of the global health priority. In the past few years, there have been many p...

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Detalles Bibliográficos
Autores principales: Wang, Hai-Bo, Mo, Qiu-Hua, Yang, Ze
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377490/
https://www.ncbi.nlm.nih.gov/pubmed/25861656
http://dx.doi.org/10.1155/2015/503978
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author Wang, Hai-Bo
Mo, Qiu-Hua
Yang, Ze
author_facet Wang, Hai-Bo
Mo, Qiu-Hua
Yang, Ze
author_sort Wang, Hai-Bo
collection PubMed
description Human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) is a worldwide epidemic, with over 35 million people infected currently. Therefore, the development of a safe and effective HIV-1 vaccine is on top of the global health priority. In the past few years, there have been many promising advances in the prevention of HIV/AIDS, among which the RV144 Thai trial has been encouraging and suggests optimization of the current vaccine strategies or search for novel strategies. Here we reviewed the brief history of HIV-1 vaccine, analyzed key challenges existing now, and illustrated future research priority/directions for a therapeutic or prophylactic HIV-1 vaccine, with the hope of accelerating the speed of vaccine development. We believe that an effective HIV-1 vaccine, together with other prevention approaches, will bring an end to this epidemic in the near future.
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spelling pubmed-43774902015-04-08 HIV Vaccine Research: The Challenge and the Way Forward Wang, Hai-Bo Mo, Qiu-Hua Yang, Ze J Immunol Res Review Article Human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) is a worldwide epidemic, with over 35 million people infected currently. Therefore, the development of a safe and effective HIV-1 vaccine is on top of the global health priority. In the past few years, there have been many promising advances in the prevention of HIV/AIDS, among which the RV144 Thai trial has been encouraging and suggests optimization of the current vaccine strategies or search for novel strategies. Here we reviewed the brief history of HIV-1 vaccine, analyzed key challenges existing now, and illustrated future research priority/directions for a therapeutic or prophylactic HIV-1 vaccine, with the hope of accelerating the speed of vaccine development. We believe that an effective HIV-1 vaccine, together with other prevention approaches, will bring an end to this epidemic in the near future. Hindawi Publishing Corporation 2015 2015-03-15 /pmc/articles/PMC4377490/ /pubmed/25861656 http://dx.doi.org/10.1155/2015/503978 Text en Copyright © 2015 Hai-Bo Wang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wang, Hai-Bo
Mo, Qiu-Hua
Yang, Ze
HIV Vaccine Research: The Challenge and the Way Forward
title HIV Vaccine Research: The Challenge and the Way Forward
title_full HIV Vaccine Research: The Challenge and the Way Forward
title_fullStr HIV Vaccine Research: The Challenge and the Way Forward
title_full_unstemmed HIV Vaccine Research: The Challenge and the Way Forward
title_short HIV Vaccine Research: The Challenge and the Way Forward
title_sort hiv vaccine research: the challenge and the way forward
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377490/
https://www.ncbi.nlm.nih.gov/pubmed/25861656
http://dx.doi.org/10.1155/2015/503978
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