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Functional MRI neurofeedback training on connectivity between two regions induces long-lasting changes in intrinsic functional network

Motor or perceptual learning is known to influence functional connectivity between brain regions and induce short-term changes in the intrinsic functional networks revealed as correlations in slow blood-oxygen-level dependent (BOLD) signal fluctuations. However, no cause-and-effect relationship has...

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Autores principales: Megumi, Fukuda, Yamashita, Ayumu, Kawato, Mitsuo, Imamizu, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377493/
https://www.ncbi.nlm.nih.gov/pubmed/25870552
http://dx.doi.org/10.3389/fnhum.2015.00160
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author Megumi, Fukuda
Yamashita, Ayumu
Kawato, Mitsuo
Imamizu, Hiroshi
author_facet Megumi, Fukuda
Yamashita, Ayumu
Kawato, Mitsuo
Imamizu, Hiroshi
author_sort Megumi, Fukuda
collection PubMed
description Motor or perceptual learning is known to influence functional connectivity between brain regions and induce short-term changes in the intrinsic functional networks revealed as correlations in slow blood-oxygen-level dependent (BOLD) signal fluctuations. However, no cause-and-effect relationship has been elucidated between a specific change in connectivity and a long-term change in global networks. Here, we examine the hypothesis that functional connectivity (i.e., temporal correlation between two regions) is increased and preserved for a long time when two regions are simultaneously activated or deactivated. Using the connectivity-neurofeedback training paradigm, subjects successfully learned to increase the correlation of activity between the lateral parietal and primary motor areas, regions that belong to different intrinsic networks and negatively correlated before training under the resting conditions. Furthermore, whole-brain hypothesis-free analysis as well as functional network analyses demonstrated that the correlation in the resting state between these areas as well as the correlation between the intrinsic networks that include the areas increased for at least 2 months. These findings indicate that the connectivity-neurofeedback training can cause long-term changes in intrinsic connectivity and that intrinsic networks can be shaped by experience-driven modulation of regional correlation.
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spelling pubmed-43774932015-04-13 Functional MRI neurofeedback training on connectivity between two regions induces long-lasting changes in intrinsic functional network Megumi, Fukuda Yamashita, Ayumu Kawato, Mitsuo Imamizu, Hiroshi Front Hum Neurosci Neuroscience Motor or perceptual learning is known to influence functional connectivity between brain regions and induce short-term changes in the intrinsic functional networks revealed as correlations in slow blood-oxygen-level dependent (BOLD) signal fluctuations. However, no cause-and-effect relationship has been elucidated between a specific change in connectivity and a long-term change in global networks. Here, we examine the hypothesis that functional connectivity (i.e., temporal correlation between two regions) is increased and preserved for a long time when two regions are simultaneously activated or deactivated. Using the connectivity-neurofeedback training paradigm, subjects successfully learned to increase the correlation of activity between the lateral parietal and primary motor areas, regions that belong to different intrinsic networks and negatively correlated before training under the resting conditions. Furthermore, whole-brain hypothesis-free analysis as well as functional network analyses demonstrated that the correlation in the resting state between these areas as well as the correlation between the intrinsic networks that include the areas increased for at least 2 months. These findings indicate that the connectivity-neurofeedback training can cause long-term changes in intrinsic connectivity and that intrinsic networks can be shaped by experience-driven modulation of regional correlation. Frontiers Media S.A. 2015-03-30 /pmc/articles/PMC4377493/ /pubmed/25870552 http://dx.doi.org/10.3389/fnhum.2015.00160 Text en Copyright © 2015 Megumi, Yamashita, Kawato and Imamizu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Megumi, Fukuda
Yamashita, Ayumu
Kawato, Mitsuo
Imamizu, Hiroshi
Functional MRI neurofeedback training on connectivity between two regions induces long-lasting changes in intrinsic functional network
title Functional MRI neurofeedback training on connectivity between two regions induces long-lasting changes in intrinsic functional network
title_full Functional MRI neurofeedback training on connectivity between two regions induces long-lasting changes in intrinsic functional network
title_fullStr Functional MRI neurofeedback training on connectivity between two regions induces long-lasting changes in intrinsic functional network
title_full_unstemmed Functional MRI neurofeedback training on connectivity between two regions induces long-lasting changes in intrinsic functional network
title_short Functional MRI neurofeedback training on connectivity between two regions induces long-lasting changes in intrinsic functional network
title_sort functional mri neurofeedback training on connectivity between two regions induces long-lasting changes in intrinsic functional network
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377493/
https://www.ncbi.nlm.nih.gov/pubmed/25870552
http://dx.doi.org/10.3389/fnhum.2015.00160
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