Cargando…

Evaluation of Sedative and Hypnotic Activity of Ethanolic Extract of Scoparia dulcis Linn.

Scoparia dulcis Linn. (SD) is a perennial herb that has been well studied for its antioxidant, anti-inflammatory, antidiabetic, and hepatoprotective effects. However, scientific information on SD regarding the neuropharmacological effect is limited. This study evaluated the sedative and hypnotic eff...

Descripción completa

Detalles Bibliográficos
Autores principales: Moniruzzaman, Md., Atikur Rahman, Md., Ferdous, Afia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377517/
https://www.ncbi.nlm.nih.gov/pubmed/25861372
http://dx.doi.org/10.1155/2015/873954
_version_ 1782363927282188288
author Moniruzzaman, Md.
Atikur Rahman, Md.
Ferdous, Afia
author_facet Moniruzzaman, Md.
Atikur Rahman, Md.
Ferdous, Afia
author_sort Moniruzzaman, Md.
collection PubMed
description Scoparia dulcis Linn. (SD) is a perennial herb that has been well studied for its antioxidant, anti-inflammatory, antidiabetic, and hepatoprotective effects. However, scientific information on SD regarding the neuropharmacological effect is limited. This study evaluated the sedative and hypnotic effect of the ethanolic extract of whole plants of Scoparia dulcis (EESD). For this purpose, the whole plants of S. dulcis were extracted with ethanol following maceration process and tested for the presence of phytochemical constituents. The sedative and hypnotic activity were then investigated using hole cross, open field, hole-board, rota-rod, and thiopental sodium-induced sleeping time determination tests in mice at the doses of 50, 100, and 200 mg/kg of EESD. Diazepam at the dose of 1 mg/kg was used as a reference drug in all the experiments. We found that EESD produced a significant dose-dependent inhibition of locomotor activity of mice both in hole cross and open field tests (P < 0.05). Besides, it also decreased rota-rod performances and the number of head dips in hole-board test. Furthermore, EESD significantly decreased the induction time to sleep and prolonged the duration of sleeping, induced by thiopental sodium. Taken together, our study suggests that EESD may possess sedative principles with potent hypnotic properties.
format Online
Article
Text
id pubmed-4377517
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-43775172015-04-08 Evaluation of Sedative and Hypnotic Activity of Ethanolic Extract of Scoparia dulcis Linn. Moniruzzaman, Md. Atikur Rahman, Md. Ferdous, Afia Evid Based Complement Alternat Med Research Article Scoparia dulcis Linn. (SD) is a perennial herb that has been well studied for its antioxidant, anti-inflammatory, antidiabetic, and hepatoprotective effects. However, scientific information on SD regarding the neuropharmacological effect is limited. This study evaluated the sedative and hypnotic effect of the ethanolic extract of whole plants of Scoparia dulcis (EESD). For this purpose, the whole plants of S. dulcis were extracted with ethanol following maceration process and tested for the presence of phytochemical constituents. The sedative and hypnotic activity were then investigated using hole cross, open field, hole-board, rota-rod, and thiopental sodium-induced sleeping time determination tests in mice at the doses of 50, 100, and 200 mg/kg of EESD. Diazepam at the dose of 1 mg/kg was used as a reference drug in all the experiments. We found that EESD produced a significant dose-dependent inhibition of locomotor activity of mice both in hole cross and open field tests (P < 0.05). Besides, it also decreased rota-rod performances and the number of head dips in hole-board test. Furthermore, EESD significantly decreased the induction time to sleep and prolonged the duration of sleeping, induced by thiopental sodium. Taken together, our study suggests that EESD may possess sedative principles with potent hypnotic properties. Hindawi Publishing Corporation 2015 2015-03-12 /pmc/articles/PMC4377517/ /pubmed/25861372 http://dx.doi.org/10.1155/2015/873954 Text en Copyright © 2015 Md. Moniruzzaman et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Moniruzzaman, Md.
Atikur Rahman, Md.
Ferdous, Afia
Evaluation of Sedative and Hypnotic Activity of Ethanolic Extract of Scoparia dulcis Linn.
title Evaluation of Sedative and Hypnotic Activity of Ethanolic Extract of Scoparia dulcis Linn.
title_full Evaluation of Sedative and Hypnotic Activity of Ethanolic Extract of Scoparia dulcis Linn.
title_fullStr Evaluation of Sedative and Hypnotic Activity of Ethanolic Extract of Scoparia dulcis Linn.
title_full_unstemmed Evaluation of Sedative and Hypnotic Activity of Ethanolic Extract of Scoparia dulcis Linn.
title_short Evaluation of Sedative and Hypnotic Activity of Ethanolic Extract of Scoparia dulcis Linn.
title_sort evaluation of sedative and hypnotic activity of ethanolic extract of scoparia dulcis linn.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377517/
https://www.ncbi.nlm.nih.gov/pubmed/25861372
http://dx.doi.org/10.1155/2015/873954
work_keys_str_mv AT moniruzzamanmd evaluationofsedativeandhypnoticactivityofethanolicextractofscopariadulcislinn
AT atikurrahmanmd evaluationofsedativeandhypnoticactivityofethanolicextractofscopariadulcislinn
AT ferdousafia evaluationofsedativeandhypnoticactivityofethanolicextractofscopariadulcislinn