Sustained complete remission of steroid- and cyclophosphamide-resistant minimal-change disease with a single course of rituximab therapy

We report a case of steroid- and cyclophosphamide-resistant nephrotic syndrome secondary to minimal-change disease occurring in an otherwise healthy 19-year-old female, responding rapidly to two doses of rituximab therapy. Complete disease remission has been sustained up to last follow-up (32 months...

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Detalles Bibliográficos
Autores principales: Janardan, Jyotsna, Ooi, Khai, Menahem, Solomon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Clinical Cases
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377744/
https://www.ncbi.nlm.nih.gov/pubmed/25852892
http://dx.doi.org/10.1093/ckj/sfu022
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author Janardan, Jyotsna
Ooi, Khai
Menahem, Solomon
author_facet Janardan, Jyotsna
Ooi, Khai
Menahem, Solomon
author_sort Janardan, Jyotsna
collection PubMed
description We report a case of steroid- and cyclophosphamide-resistant nephrotic syndrome secondary to minimal-change disease occurring in an otherwise healthy 19-year-old female, responding rapidly to two doses of rituximab therapy. Complete disease remission has been sustained up to last follow-up (32 months) despite CD19 recovery. Literature review suggests emerging evidence that rituximab may have a role to play in recurrent and/or refractory minimal-change disease.
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spelling pubmed-43777442015-04-07 Sustained complete remission of steroid- and cyclophosphamide-resistant minimal-change disease with a single course of rituximab therapy Janardan, Jyotsna Ooi, Khai Menahem, Solomon Clin Kidney J Clinical Cases We report a case of steroid- and cyclophosphamide-resistant nephrotic syndrome secondary to minimal-change disease occurring in an otherwise healthy 19-year-old female, responding rapidly to two doses of rituximab therapy. Complete disease remission has been sustained up to last follow-up (32 months) despite CD19 recovery. Literature review suggests emerging evidence that rituximab may have a role to play in recurrent and/or refractory minimal-change disease. Oxford University Press 2014-06 2014-03-16 /pmc/articles/PMC4377744/ /pubmed/25852892 http://dx.doi.org/10.1093/ckj/sfu022 Text en © The Author 2014. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For permissions, please email: journals.permissions@oup.com. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Clinical Cases
Janardan, Jyotsna
Ooi, Khai
Menahem, Solomon
Sustained complete remission of steroid- and cyclophosphamide-resistant minimal-change disease with a single course of rituximab therapy
title Sustained complete remission of steroid- and cyclophosphamide-resistant minimal-change disease with a single course of rituximab therapy
title_full Sustained complete remission of steroid- and cyclophosphamide-resistant minimal-change disease with a single course of rituximab therapy
title_fullStr Sustained complete remission of steroid- and cyclophosphamide-resistant minimal-change disease with a single course of rituximab therapy
title_full_unstemmed Sustained complete remission of steroid- and cyclophosphamide-resistant minimal-change disease with a single course of rituximab therapy
title_short Sustained complete remission of steroid- and cyclophosphamide-resistant minimal-change disease with a single course of rituximab therapy
title_sort sustained complete remission of steroid- and cyclophosphamide-resistant minimal-change disease with a single course of rituximab therapy
topic Clinical Cases
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377744/
https://www.ncbi.nlm.nih.gov/pubmed/25852892
http://dx.doi.org/10.1093/ckj/sfu022
work_keys_str_mv AT janardanjyotsna sustainedcompleteremissionofsteroidandcyclophosphamideresistantminimalchangediseasewithasinglecourseofrituximabtherapy
AT ooikhai sustainedcompleteremissionofsteroidandcyclophosphamideresistantminimalchangediseasewithasinglecourseofrituximabtherapy
AT menahemsolomon sustainedcompleteremissionofsteroidandcyclophosphamideresistantminimalchangediseasewithasinglecourseofrituximabtherapy

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