Crystalloid glomerulopathy in monoclonal gammopathy of renal significance (MGRS)

We report a case of monoclonal gammopathy of renal significance in a 63-year-old man who presented with nephrotic-range proteinuria and renal insufficiency. The kidney biopsy showed a membranoproliferative glomerulonephritis pattern with extensive crystalloid deposits in the glomerular capillary end...

Descripción completa

Detalles Bibliográficos
Autores principales: Vankalakunti, Mahesha, Bonu, Ravishankar, Shetty, Shilpa, Siddini, Vishwanath, Babu, Kishore, Ballal, Sudarshan H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Clinical Cases
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377747/
https://www.ncbi.nlm.nih.gov/pubmed/25852893
http://dx.doi.org/10.1093/ckj/sfu025
Descripción
Sumario:We report a case of monoclonal gammopathy of renal significance in a 63-year-old man who presented with nephrotic-range proteinuria and renal insufficiency. The kidney biopsy showed a membranoproliferative glomerulonephritis pattern with extensive crystalloid deposits in the glomerular capillary endothelial cells and very few in the tubular epithelial cells. The immunoperoxidase staining showed kappa light chain restriction. Subsequently, the bone marrow showed 6% plasma cells which confirmed the diagnosis of monoclonal gammopathy of renal significance. He responded well to bortezomib treatment with resolution of the nephrotic syndrome and normalization of renal function after 7 months.

Ejemplares similares