LKB1 and AMPK differentially regulate pancreatic β-cell identity

Fully differentiated pancreatic β cells are essential for normal glucose homeostasis in mammals. Dedifferentiation of these cells has been suggested to occur in type 2 diabetes, impairing insulin production. Since chronic fuel excess (“glucotoxicity”) is implicated in this process, we sought here to...

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Detalles Bibliográficos
Autores principales: Kone, Marina, Pullen, Timothy J., Sun, Gao, Ibberson, Mark, Martinez-Sanchez, Aida, Sayers, Sophie, Nguyen-Tu, Marie-Sophie, Kantor, Chase, Swisa, Avital, Dor, Yuval, Gorman, Tracy, Ferrer, Jorge, Thorens, Bernard, Reimann, Frank, Gribble, Fiona, McGinty, James A., Chen, Lingling, French, Paul M., Birzele, Fabian, Hildebrandt, Tobias, Uphues, Ingo, Rutter, Guy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Federation of American Societies for Experimental Biology 2014
Materias:
Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377859/
https://www.ncbi.nlm.nih.gov/pubmed/25070369
http://dx.doi.org/10.1096/fj.14-257667

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