Cargando…

Salacinol and Related Analogs: New Leads for Type 2 Diabetes Therapeutic Candidates from the Thai Traditional Natural Medicine Salacia chinensis

The antidiabetic effect of a hot water extract of stems of Salacia chinensis (SCE) was evaluated in vivo in KK-A(y) mice, a typical type 2 diabetes mellitus mice model. Administration of CE-2 dietary feed containing 0.25 and/or 0.50% of SCE for three weeks to KK-A(y) mice significantly suppressed th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Morikawa, Toshio, Akaki, Junji, Ninomiya, Kiyofumi, Kinouchi, Eri, Tanabe, Genzoh, Pongpiriyadacha, Yutana, Yoshikawa, Masayuki, Muraoka, Osamu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377863/ https://www.ncbi.nlm.nih.gov/pubmed/25734563 http://dx.doi.org/10.3390/nu7031480

Ejemplares similares

A review of antidiabetic active thiosugar sulfoniums, salacinol and neokotalanol, from plants of the genus Salacia
por: Morikawa, Toshio, et al.
Publicado: (2021)

Ligand compatibility of salacinol-type α-glucosidase inhibitors toward the GH31 family
por: Ishikawa, Fumihiro, et al.
Publicado: (2021)

Geranylated Coumarins From Thai Medicinal Plant Mammea siamensis With Testosterone 5α-Reductase Inhibitory Activity
por: Morikawa, Toshio, et al.
Publicado: (2020)

Quantitative Determination of Stilbenoids and Dihydroisocoumarins in Shorea roxburghii and Evaluation of Their Hepatoprotective Activity
por: Ninomiya, Kiyofumi, et al.
Publicado: (2017)

Phytochemicals with Chemopreventive Activity Obtained from the Thai Medicinal Plant Mammea siamensis (Miq.) T. Anders.: Isolation and Structure Determination of New Prenylcoumarins with Inhibitory Activity against Aromatase
por: Luo, Fenglin, et al.
Publicado: (2022)

Structures of Mammeasins P and Q, Coumarin-Related Polysubstituted Benzofurans, from the Thai Medicinal Plant Mammea siamensis (Miq.) T. Anders.: Anti-Proliferative Activity of Coumarin Constituents against Human Prostate Carcinoma Cell Line LNCaP
por: Luo, Fenglin, et al.
Publicado: (2023)

Quantitative Determination of Alkaloids in Lotus Flower (Flower Buds of Nelumbo nucifera) and Their Melanogenesis Inhibitory Activity
por: Morikawa, Toshio, et al.
Publicado: (2016)

Assessment of the effect and safety of salacinol in horses
por: UEDA, Fumitaka, et al.
Publicado: (2019)

Dipeptidyl peptidase-IV inhibitory activity of dimeric dihydrochalcone glycosides from flowers of Helichrysum arenarium
por: Morikawa, Toshio, et al.
Publicado: (2015)

The Antiproliferative Effect of Chakasaponins I and II, Floratheasaponin A, and Epigallocatechin 3-O-Gallate Isolated from Camellia sinensis on Human Digestive Tract Carcinoma Cell Lines
por: Kitagawa, Niichiro, et al.
Publicado: (2016)

Antihyperlipidemic activity of Salacia chinensis root extracts in triton-induced and atherogenic diet-induced hyperlipidemic rats
por: Sikarwar, Mukesh S., et al.
Publicado: (2012)

The effects of a nutritional supplement containing salacinol in neonatal Thoroughbred foals
por: IIDA, Atsushi, et al.
Publicado: (2020)

Labdane-Type Diterpenes, Galangalditerpenes A–C, with Melanogenesis Inhibitory Activity from the Fruit of Alpinia galanga
por: Manse, Yoshiaki, et al.
Publicado: (2017)

Extraction efficiency, phytochemical profiles and antioxidative properties of different parts of Saptarangi (Salacia chinensis L.) – An important underutilized plant
por: Ghadage, Dhanaji M., et al.
Publicado: (2017)

Mutagenicity assessment of Salacia chinensis by bacterial reverse mutation assay using histidine dependent Salmonella typhimurium tester strains
por: Reddi Nagesh, Madhuranthakam, et al.
Publicado: (2022)

PHARMACEUTICAL INVESTIGATIONS ON SALACIA MACROSPERMA-1
por: Venkateswarlu, V., et al.
Publicado: (1990)

Hepatoprotective Limonoids from Andiroba (Carapa guianensis)
por: Ninomiya, Kiyofumi, et al.
Publicado: (2016)

Glucose Tolerance-Improving Activity of Helichrysoside in Mice and Its Structural Requirements for Promoting Glucose and Lipid Metabolism
por: Morikawa, Toshio, et al.
Publicado: (2019)

Antimicrobial Activity of Root Bark of Salacia reticulata
por: Choudhary, G. P., et al.
Publicado: (2005)

ANTIMICROBIAL ACTIVITY OF CHEMOCONSTITUENTS OF ROOTS OF SALACIA MACROSPERMA
por: Venkatesarulu, V., et al.
Publicado: (1992)

Salacia – The new multi-targeted approach in diabetics
por: Vyas, Neera, et al.
Publicado: (2016)

Unprecedented nucleophile-promoted 1,7-S or Se shift reactions under Pummerer reaction conditions of 4-alkenyl-3-sulfinylmethylpyrroles
por: Go, Takashi, et al.
Publicado: (2018)

New biofunctional effects of the flower buds of Camellia sinensis and its bioactive acylated oleanane-type triterpene oligoglycosides
por: Matsuda, Hisashi, et al.
Publicado: (2016)

New biofunctional effects of oleanane-type triterpene saponins
por: Matsuda, Hisashi, et al.
Publicado: (2023)

Publisher Correction: New biofunctional effects of oleanane-type triterpene saponins
por: Matsuda, Hisashi, et al.
Publicado: (2023)

Appetite and Gut Hormones Response to a Putative α-Glucosidase Inhibitor, Salacia Chinensis, in Overweight/Obese Adults: A Double Blind Randomized Controlled Trial
por: Hao, Lihong, et al.
Publicado: (2017)

An Updated Review on the Phytochemistry, Pharmacology, and Clinical Trials of Salacia oblonga
por: Kushwaha, Priya Singh, et al.
Publicado: (2016)

Antimicrobial and toxicological evaluation of ethanol leaf extract of Salacia lehmbachii
por: Essien, Augustine Dick, et al.
Publicado: (2017)

A Gedunin-Type Limonoid, 7-Deacetoxy-7-Oxogedunin, from Andiroba (Carapa guianensis Aublet) Reduced Intracellular Triglyceride Content and Enhanced Autophagy in HepG2 Cells
por: Nagatomo, Akifumi, et al.
Publicado: (2022)

Preventive Effects of Salacia reticulata on Obesity and Metabolic Disorders in TSOD Mice
por: Akase, Tomoko, et al.
Publicado: (2011)

Cytotoxic Triterpenes from Salacia crassifolia and Metabolite Profiling of Celastraceae Species
por: Espindola, Laila S., et al.
Publicado: (2018)

Salacia reticulata Extract Suppresses Fat Accumulation by Regulating Lipid Metabolism
por: Jung, Jaeeun, et al.
Publicado: (2023)

Salacia chinensis L. Stem Extract Exerts Antifibrotic Effects on Human Hepatic Stellate Cells through the Inhibition of the TGF-β1-Induced SMAD2/3 Signaling Pathway
por: Phaosri, Mattareeyapar, et al.
Publicado: (2019)

Design, Synthesis and Biological Evaluation of Nitrate Derivatives of Sauropunol A and B as Potent Vasodilatory Agents
por: Lu, Lu, et al.
Publicado: (2019)

Role of medicinal plant Salacia Reticulata in the management of Type II Diabetic Subjects
por: Radha, R., et al.
Publicado: (2009)

Anti‐diabetic and Anti‐hyperlipidemic Effects and Safety of Salacia reticulata and Related Species
por: Stohs, Sidney J., et al.
Publicado: (2015)

A subchronic oral toxicity study of Salacia reticulata extract powder in rats
por: Oda, Yuriko, et al.
Publicado: (2015)

Salacia reticulata (Kothala himbutu) revisited; a missed opportunity to treat diabetes and obesity?
por: Medagama, Arjuna B
Publicado: (2015)

Benefits of Soleris(®) over the Conventional Method for Enumeration of Microbial Load in Salacia Herbal Extract
por: YEWALE, SADANAND, et al.
Publicado: (2020)

Structural Requirements of Alkylglyceryl-l-Ascorbic Acid Derivatives for Melanogenesis Inhibitory Activity
por: Taira, Norihisa, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_8bb9n2u9ivffuieu4j792nusmg