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Emphasizing the Health Benefits of Vitamin D for Those with Neurodevelopmental Disorders and Intellectual Disabilities

People with neurodevelopmental disorders and intellectual disabilities have much greater health care needs. Mainly staying indoors, such people generally have low 25-hydroxyvitamin D (25(OH)D) concentrations. The Vitamin D Task Force of the American Academy of Developmental Medicine and Dentistry (A...

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Autores principales: Grant, William B., Wimalawansa, Sunil J., Holick, Michael F., Cannell, John J., Pludowski, Pawel, Lappe, Joan M., Pittaway, Mary, May, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377865/
https://www.ncbi.nlm.nih.gov/pubmed/25734565
http://dx.doi.org/10.3390/nu7031538
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author Grant, William B.
Wimalawansa, Sunil J.
Holick, Michael F.
Cannell, John J.
Pludowski, Pawel
Lappe, Joan M.
Pittaway, Mary
May, Philip
author_facet Grant, William B.
Wimalawansa, Sunil J.
Holick, Michael F.
Cannell, John J.
Pludowski, Pawel
Lappe, Joan M.
Pittaway, Mary
May, Philip
author_sort Grant, William B.
collection PubMed
description People with neurodevelopmental disorders and intellectual disabilities have much greater health care needs. Mainly staying indoors, such people generally have low 25-hydroxyvitamin D (25(OH)D) concentrations. The Vitamin D Task Force of the American Academy of Developmental Medicine and Dentistry (AADMD) reviewed the evidence of 25(OH)D concentrations that benefit the health of persons with developmental disabilities. Maintaining recommended optimal serum 25(OH)D concentrations year long will benefit skeletal development in infants, children, and adolescents, and benefit musculoskeletal health and neuromuscular coordination in adult patients, and decrease risk of falls. Maintaining optimal concentrations decreases risks and severities of autoimmune diseases, cardiovascular disease, many types of cancer, dementia, types 1 and 2 diabetes mellitus, and respiratory tract infections. Other benefits include improved dental and oral health and improved physical performance. The Task Force recommends that 25(OH)D concentrations for optimal health to be in the range of 75 to 125 nmol/L, which can be achieved using between 800 and 4000 IU/day vitamin D(3) and sensible exposure to solar UVB radiation. The paper also discusses the potential risks of higher 25(OH)D concentrations, the evidence from and limitations of randomized controlled trials, and the recommendations by various groups and agencies.
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spelling pubmed-43778652015-04-30 Emphasizing the Health Benefits of Vitamin D for Those with Neurodevelopmental Disorders and Intellectual Disabilities Grant, William B. Wimalawansa, Sunil J. Holick, Michael F. Cannell, John J. Pludowski, Pawel Lappe, Joan M. Pittaway, Mary May, Philip Nutrients Review People with neurodevelopmental disorders and intellectual disabilities have much greater health care needs. Mainly staying indoors, such people generally have low 25-hydroxyvitamin D (25(OH)D) concentrations. The Vitamin D Task Force of the American Academy of Developmental Medicine and Dentistry (AADMD) reviewed the evidence of 25(OH)D concentrations that benefit the health of persons with developmental disabilities. Maintaining recommended optimal serum 25(OH)D concentrations year long will benefit skeletal development in infants, children, and adolescents, and benefit musculoskeletal health and neuromuscular coordination in adult patients, and decrease risk of falls. Maintaining optimal concentrations decreases risks and severities of autoimmune diseases, cardiovascular disease, many types of cancer, dementia, types 1 and 2 diabetes mellitus, and respiratory tract infections. Other benefits include improved dental and oral health and improved physical performance. The Task Force recommends that 25(OH)D concentrations for optimal health to be in the range of 75 to 125 nmol/L, which can be achieved using between 800 and 4000 IU/day vitamin D(3) and sensible exposure to solar UVB radiation. The paper also discusses the potential risks of higher 25(OH)D concentrations, the evidence from and limitations of randomized controlled trials, and the recommendations by various groups and agencies. MDPI 2015-02-27 /pmc/articles/PMC4377865/ /pubmed/25734565 http://dx.doi.org/10.3390/nu7031538 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Grant, William B.
Wimalawansa, Sunil J.
Holick, Michael F.
Cannell, John J.
Pludowski, Pawel
Lappe, Joan M.
Pittaway, Mary
May, Philip
Emphasizing the Health Benefits of Vitamin D for Those with Neurodevelopmental Disorders and Intellectual Disabilities
title Emphasizing the Health Benefits of Vitamin D for Those with Neurodevelopmental Disorders and Intellectual Disabilities
title_full Emphasizing the Health Benefits of Vitamin D for Those with Neurodevelopmental Disorders and Intellectual Disabilities
title_fullStr Emphasizing the Health Benefits of Vitamin D for Those with Neurodevelopmental Disorders and Intellectual Disabilities
title_full_unstemmed Emphasizing the Health Benefits of Vitamin D for Those with Neurodevelopmental Disorders and Intellectual Disabilities
title_short Emphasizing the Health Benefits of Vitamin D for Those with Neurodevelopmental Disorders and Intellectual Disabilities
title_sort emphasizing the health benefits of vitamin d for those with neurodevelopmental disorders and intellectual disabilities
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377865/
https://www.ncbi.nlm.nih.gov/pubmed/25734565
http://dx.doi.org/10.3390/nu7031538
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