Monoamine Oxidase A Promoter Variable Number of Tandem Repeats (MAOA-uVNTR) in Alcoholics According to Lesch Typology

Background: The aim of this study was to examine the association between the MAOA-uVNTR gene polymorphism in a homogeneous subgroups of patients with alcohol dependence categorized according to Lesch’s typology. Methods: DNA was provided from alcohol dependent (AD) patients (n = 370) and healthy con...

Descripción completa

Detalles Bibliográficos
Autores principales: Samochowiec, Agnieszka, Chęć, Magdalena, Kopaczewska, Edyta, Samochowiec, Jerzy, Lesch, Otto, Grochans, Elżbieta, Jasiewicz, Andrzej, Bienkowski, Przemyslaw, Łukasz, Kołodziej, Grzywacz, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377966/
https://www.ncbi.nlm.nih.gov/pubmed/25809512
http://dx.doi.org/10.3390/ijerph120303317
_version_ 1782363997542023168
author Samochowiec, Agnieszka
Chęć, Magdalena
Kopaczewska, Edyta
Samochowiec, Jerzy
Lesch, Otto
Grochans, Elżbieta
Jasiewicz, Andrzej
Bienkowski, Przemyslaw
Łukasz, Kołodziej
Grzywacz, Anna
author_facet Samochowiec, Agnieszka
Chęć, Magdalena
Kopaczewska, Edyta
Samochowiec, Jerzy
Lesch, Otto
Grochans, Elżbieta
Jasiewicz, Andrzej
Bienkowski, Przemyslaw
Łukasz, Kołodziej
Grzywacz, Anna
author_sort Samochowiec, Agnieszka
collection PubMed
description Background: The aim of this study was to examine the association between the MAOA-uVNTR gene polymorphism in a homogeneous subgroups of patients with alcohol dependence categorized according to Lesch’s typology. Methods: DNA was provided from alcohol dependent (AD) patients (n = 370) and healthy control subjects (n = 168) all of Polish descent. The history of alcoholism was obtained using the Polish version of the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA). Samples were genotyped using PCR methods. Results: We found no association between alcohol dependence and MAOA gene polymorphism. Conclusions: Lesch typology is a clinical consequence of the disease and its phenotypic description is too complex for a simple genetic analysis.
format Online
Article
Text
id pubmed-4377966
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-43779662015-04-27 Monoamine Oxidase A Promoter Variable Number of Tandem Repeats (MAOA-uVNTR) in Alcoholics According to Lesch Typology Samochowiec, Agnieszka Chęć, Magdalena Kopaczewska, Edyta Samochowiec, Jerzy Lesch, Otto Grochans, Elżbieta Jasiewicz, Andrzej Bienkowski, Przemyslaw Łukasz, Kołodziej Grzywacz, Anna Int J Environ Res Public Health Article Background: The aim of this study was to examine the association between the MAOA-uVNTR gene polymorphism in a homogeneous subgroups of patients with alcohol dependence categorized according to Lesch’s typology. Methods: DNA was provided from alcohol dependent (AD) patients (n = 370) and healthy control subjects (n = 168) all of Polish descent. The history of alcoholism was obtained using the Polish version of the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA). Samples were genotyped using PCR methods. Results: We found no association between alcohol dependence and MAOA gene polymorphism. Conclusions: Lesch typology is a clinical consequence of the disease and its phenotypic description is too complex for a simple genetic analysis. MDPI 2015-03-19 2015-03 /pmc/articles/PMC4377966/ /pubmed/25809512 http://dx.doi.org/10.3390/ijerph120303317 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Samochowiec, Agnieszka
Chęć, Magdalena
Kopaczewska, Edyta
Samochowiec, Jerzy
Lesch, Otto
Grochans, Elżbieta
Jasiewicz, Andrzej
Bienkowski, Przemyslaw
Łukasz, Kołodziej
Grzywacz, Anna
Monoamine Oxidase A Promoter Variable Number of Tandem Repeats (MAOA-uVNTR) in Alcoholics According to Lesch Typology
title Monoamine Oxidase A Promoter Variable Number of Tandem Repeats (MAOA-uVNTR) in Alcoholics According to Lesch Typology
title_full Monoamine Oxidase A Promoter Variable Number of Tandem Repeats (MAOA-uVNTR) in Alcoholics According to Lesch Typology
title_fullStr Monoamine Oxidase A Promoter Variable Number of Tandem Repeats (MAOA-uVNTR) in Alcoholics According to Lesch Typology
title_full_unstemmed Monoamine Oxidase A Promoter Variable Number of Tandem Repeats (MAOA-uVNTR) in Alcoholics According to Lesch Typology
title_short Monoamine Oxidase A Promoter Variable Number of Tandem Repeats (MAOA-uVNTR) in Alcoholics According to Lesch Typology
title_sort monoamine oxidase a promoter variable number of tandem repeats (maoa-uvntr) in alcoholics according to lesch typology
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377966/
https://www.ncbi.nlm.nih.gov/pubmed/25809512
http://dx.doi.org/10.3390/ijerph120303317
work_keys_str_mv AT samochowiecagnieszka monoamineoxidaseapromotervariablenumberoftandemrepeatsmaoauvntrinalcoholicsaccordingtoleschtypology
AT checmagdalena monoamineoxidaseapromotervariablenumberoftandemrepeatsmaoauvntrinalcoholicsaccordingtoleschtypology
AT kopaczewskaedyta monoamineoxidaseapromotervariablenumberoftandemrepeatsmaoauvntrinalcoholicsaccordingtoleschtypology
AT samochowiecjerzy monoamineoxidaseapromotervariablenumberoftandemrepeatsmaoauvntrinalcoholicsaccordingtoleschtypology
AT leschotto monoamineoxidaseapromotervariablenumberoftandemrepeatsmaoauvntrinalcoholicsaccordingtoleschtypology
AT grochanselzbieta monoamineoxidaseapromotervariablenumberoftandemrepeatsmaoauvntrinalcoholicsaccordingtoleschtypology
AT jasiewiczandrzej monoamineoxidaseapromotervariablenumberoftandemrepeatsmaoauvntrinalcoholicsaccordingtoleschtypology
AT bienkowskiprzemyslaw monoamineoxidaseapromotervariablenumberoftandemrepeatsmaoauvntrinalcoholicsaccordingtoleschtypology
AT łukaszkołodziej monoamineoxidaseapromotervariablenumberoftandemrepeatsmaoauvntrinalcoholicsaccordingtoleschtypology
AT grzywaczanna monoamineoxidaseapromotervariablenumberoftandemrepeatsmaoauvntrinalcoholicsaccordingtoleschtypology

Ejemplares similares