Bioactive Isopimarane Diterpenes from the Fungus, Epicoccum sp. HS-1, Associated with Apostichopus japonicus

One new isopimarane diterpene (1), together with two known compounds, 11-deoxydiaporthein A (2) and iso-pimara-8(14),15-diene (3) were isolated from the culture of Epicoccum sp., which was associated with Apostichopus japonicus. Their structures were determined by the analysis of 1D and 2D NMR, as w...

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Autores principales: Xia, Xuekui, Qi, Jun, Liu, Yayue, Jia, Airong, Zhang, Yonggang, Liu, Changheng, Gao, Cuiling, She, Zhigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377976/
https://www.ncbi.nlm.nih.gov/pubmed/25738327
http://dx.doi.org/10.3390/md13031124
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author Xia, Xuekui
Qi, Jun
Liu, Yayue
Jia, Airong
Zhang, Yonggang
Liu, Changheng
Gao, Cuiling
She, Zhigang
author_facet Xia, Xuekui
Qi, Jun
Liu, Yayue
Jia, Airong
Zhang, Yonggang
Liu, Changheng
Gao, Cuiling
She, Zhigang
author_sort Xia, Xuekui
collection PubMed
description One new isopimarane diterpene (1), together with two known compounds, 11-deoxydiaporthein A (2) and iso-pimara-8(14),15-diene (3) were isolated from the culture of Epicoccum sp., which was associated with Apostichopus japonicus. Their structures were determined by the analysis of 1D and 2D NMR, as well as mass spectroscopic data. The absolute configuration of Compound 1 was deduced by a single-crystal X-ray diffraction experiment using CuKα radiation. In the bioactivity assay, both Compounds 1 and 2 exhibited α-glucosidase inhibitory activity with IC(50) values of 4.6 ± 0.1 and 11.9 ± 0.4 μM, respectively. This was the first report on isopimarane diterpenes with α-glucosidase inhibitory activity.
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spelling pubmed-43779762015-04-27 Bioactive Isopimarane Diterpenes from the Fungus, Epicoccum sp. HS-1, Associated with Apostichopus japonicus Xia, Xuekui Qi, Jun Liu, Yayue Jia, Airong Zhang, Yonggang Liu, Changheng Gao, Cuiling She, Zhigang Mar Drugs Article One new isopimarane diterpene (1), together with two known compounds, 11-deoxydiaporthein A (2) and iso-pimara-8(14),15-diene (3) were isolated from the culture of Epicoccum sp., which was associated with Apostichopus japonicus. Their structures were determined by the analysis of 1D and 2D NMR, as well as mass spectroscopic data. The absolute configuration of Compound 1 was deduced by a single-crystal X-ray diffraction experiment using CuKα radiation. In the bioactivity assay, both Compounds 1 and 2 exhibited α-glucosidase inhibitory activity with IC(50) values of 4.6 ± 0.1 and 11.9 ± 0.4 μM, respectively. This was the first report on isopimarane diterpenes with α-glucosidase inhibitory activity. MDPI 2015-03-02 /pmc/articles/PMC4377976/ /pubmed/25738327 http://dx.doi.org/10.3390/md13031124 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Xia, Xuekui
Qi, Jun
Liu, Yayue
Jia, Airong
Zhang, Yonggang
Liu, Changheng
Gao, Cuiling
She, Zhigang
Bioactive Isopimarane Diterpenes from the Fungus, Epicoccum sp. HS-1, Associated with Apostichopus japonicus
title Bioactive Isopimarane Diterpenes from the Fungus, Epicoccum sp. HS-1, Associated with Apostichopus japonicus
title_full Bioactive Isopimarane Diterpenes from the Fungus, Epicoccum sp. HS-1, Associated with Apostichopus japonicus
title_fullStr Bioactive Isopimarane Diterpenes from the Fungus, Epicoccum sp. HS-1, Associated with Apostichopus japonicus
title_full_unstemmed Bioactive Isopimarane Diterpenes from the Fungus, Epicoccum sp. HS-1, Associated with Apostichopus japonicus
title_short Bioactive Isopimarane Diterpenes from the Fungus, Epicoccum sp. HS-1, Associated with Apostichopus japonicus
title_sort bioactive isopimarane diterpenes from the fungus, epicoccum sp. hs-1, associated with apostichopus japonicus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377976/
https://www.ncbi.nlm.nih.gov/pubmed/25738327
http://dx.doi.org/10.3390/md13031124
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