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Anticancer Activity of Sea Cucumber Triterpene Glycosides

Triterpene glycosides are characteristic secondary metabolites of sea cucumbers (Holothurioidea, Echinodermata). They have hemolytic, cytotoxic, antifungal, and other biological activities caused by membranotropic action. These natural products suppress the proliferation of various human tumor cell...

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Autores principales: Aminin, Dmitry L., Menchinskaya, Ekaterina S., Pisliagin, Evgeny A., Silchenko, Alexandra S., Avilov, Sergey A., Kalinin, Vladimir I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377980/
https://www.ncbi.nlm.nih.gov/pubmed/25756523
http://dx.doi.org/10.3390/md13031202
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author Aminin, Dmitry L.
Menchinskaya, Ekaterina S.
Pisliagin, Evgeny A.
Silchenko, Alexandra S.
Avilov, Sergey A.
Kalinin, Vladimir I.
author_facet Aminin, Dmitry L.
Menchinskaya, Ekaterina S.
Pisliagin, Evgeny A.
Silchenko, Alexandra S.
Avilov, Sergey A.
Kalinin, Vladimir I.
author_sort Aminin, Dmitry L.
collection PubMed
description Triterpene glycosides are characteristic secondary metabolites of sea cucumbers (Holothurioidea, Echinodermata). They have hemolytic, cytotoxic, antifungal, and other biological activities caused by membranotropic action. These natural products suppress the proliferation of various human tumor cell lines in vitro and, more importantly, intraperitoneal administration in rodents of solutions of some sea cucumber triterpene glycosides significantly reduces both tumor burden and metastasis. The anticancer molecular mechanisms include the induction of tumor cell apoptosis through the activation of intracellular caspase cell death pathways, arrest of the cell cycle at S or G2/M phases, influence on nuclear factors, NF-κB, and up-down regulation of certain cellular receptors and enzymes participating in cancerogenesis, such as EGFR (epidermal growth factor receptor), Akt (protein kinase B), ERK (extracellular signal-regulated kinases), FAK (focal adhesion kinase), MMP-9 (matrix metalloproteinase-9) and others. Administration of some glycosides leads to a reduction of cancer cell adhesion, suppression of cell migration and tube formation in those cells, suppression of angiogenesis, inhibition of cell proliferation, colony formation and tumor invasion. As a result, marked growth inhibition of tumors occurs in vitro and in vivo. Some holothurian triterpene glycosides have the potential to be used as P-gp mediated MDR reversal agents in combined therapy with standard cytostatics.
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spelling pubmed-43779802015-04-27 Anticancer Activity of Sea Cucumber Triterpene Glycosides Aminin, Dmitry L. Menchinskaya, Ekaterina S. Pisliagin, Evgeny A. Silchenko, Alexandra S. Avilov, Sergey A. Kalinin, Vladimir I. Mar Drugs Review Triterpene glycosides are characteristic secondary metabolites of sea cucumbers (Holothurioidea, Echinodermata). They have hemolytic, cytotoxic, antifungal, and other biological activities caused by membranotropic action. These natural products suppress the proliferation of various human tumor cell lines in vitro and, more importantly, intraperitoneal administration in rodents of solutions of some sea cucumber triterpene glycosides significantly reduces both tumor burden and metastasis. The anticancer molecular mechanisms include the induction of tumor cell apoptosis through the activation of intracellular caspase cell death pathways, arrest of the cell cycle at S or G2/M phases, influence on nuclear factors, NF-κB, and up-down regulation of certain cellular receptors and enzymes participating in cancerogenesis, such as EGFR (epidermal growth factor receptor), Akt (protein kinase B), ERK (extracellular signal-regulated kinases), FAK (focal adhesion kinase), MMP-9 (matrix metalloproteinase-9) and others. Administration of some glycosides leads to a reduction of cancer cell adhesion, suppression of cell migration and tube formation in those cells, suppression of angiogenesis, inhibition of cell proliferation, colony formation and tumor invasion. As a result, marked growth inhibition of tumors occurs in vitro and in vivo. Some holothurian triterpene glycosides have the potential to be used as P-gp mediated MDR reversal agents in combined therapy with standard cytostatics. MDPI 2015-03-06 /pmc/articles/PMC4377980/ /pubmed/25756523 http://dx.doi.org/10.3390/md13031202 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Aminin, Dmitry L.
Menchinskaya, Ekaterina S.
Pisliagin, Evgeny A.
Silchenko, Alexandra S.
Avilov, Sergey A.
Kalinin, Vladimir I.
Anticancer Activity of Sea Cucumber Triterpene Glycosides
title Anticancer Activity of Sea Cucumber Triterpene Glycosides
title_full Anticancer Activity of Sea Cucumber Triterpene Glycosides
title_fullStr Anticancer Activity of Sea Cucumber Triterpene Glycosides
title_full_unstemmed Anticancer Activity of Sea Cucumber Triterpene Glycosides
title_short Anticancer Activity of Sea Cucumber Triterpene Glycosides
title_sort anticancer activity of sea cucumber triterpene glycosides
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377980/
https://www.ncbi.nlm.nih.gov/pubmed/25756523
http://dx.doi.org/10.3390/md13031202
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